4810-95-1

Upstream product

• 102005-09-4 4-hydroxy-4-phenyl-1-(piperidin-1-yl)butan-1-one 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 2243-53-0 styrylacetic acid 
• 110-89-4 piperidine 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 122-78-1 phenylacetaldehyde 
• 2051-95-8 succinylbenzene 
• 108-86-1 bromobenzene 
• 56058-22-1 1-Benzoyl-2,2-dichlorocyclopropane 

Downstream Products

• 102005-09-4 4-hydroxy-4-phenyl-1-(piperidin-1-yl)butan-1-one 
• 87061-59-4 2-phenyl-5-piperidinothiophene 

Relevant academic research and scientific papers

Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols

A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides.

Amides in one pot from Carboxylic Acids and Amines via Sulfinylamides

An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2- ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their a-epimerization.

Enantioselective Ruthenium(II)/Xyl-SunPhos/Daipen-Catalyzed hydrogenation of γ-Ketoamides

A0series of γ-hydroxy amides were synthesized with high ena~tioselectivities (up to 99%) usyng asymmetric hydrogenation of the corresponding γ-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of natu

Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides

Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the “good” cholesterol and as such may be useful for treating diseases such as atherosclerosis. These compounds are represented by the formula wherein: R1, R2, and R3are independently hydrogen, C1-C6alkyl, phenyl or —(CH2)1-6phenyl where phenyl is optionally substituted by halogen, cyano, nitro, C1-C6alkyl, C1-C6alkoxy, trifluoromethyl, C1-C6alkoxycarbonyl, —CO2H or OH; R4and R5are independently hydrogen, C1-C10alkyl, C3-C8cycloalkyl, —(CH2)0-6Ar1where Ar1is phenyl, naphthyl, furanyl, pyridinyl or thenyl and Ar1can be optionally substituted by halogen, cyano, nitro, C1-C6alkyl, phenyl, C1-C6alkoxy, phenoxy, trifluoromethyl, C1-C6alkoxycarbonyl, —CO2H or OH, or R4and R5together with the nitrogen to which R4and R5are attached form a ring containing 4-7 carbon atoms; and Ar is phenyl, naphthyl, furanyl, pyridinyl or thienyl which may be optionally substituted by halogen, cyano, nitro, C1-C6alkyl, C3-C6cycloalkyl, phenyl, C1-C6alkoxy, phenoxy, trifluoromethyl, C1-C6alkoxycarbonyl, —CO2H or OH.

PHOTOCYCLISATION OF KETO-LACTAMS. A NEW SYNTHESIS OF FUNCTIONALIZED 1-AZA-BICYCLO(X.Y.0.)ALKANES

A series of 1-azabicyclo(x.y.0)alkanes has been synthesized using an intramolecular photoreduction.The methodology consists of a regioselective abstraction of a hydrogen α to the nitrogen of an amide by the triplet T1(n, ?*) of a carbonyl derivative.