1020068-86-3Relevant academic research and scientific papers
Asymmetric total synthesis and X-ray crystal structure of the cytotoxic marine diterpene (+)-vigulariol
Becker, Jochen,Bergander, Klaus,Froehlich, Roland,Hoppe, Dieter
supporting information; experimental part, p. 1654 - 1657 (2009/02/06)
(Figure Presented) A crystal from the China sea: The asymmetric total synthesis of (+)-vigulariol (see picture: red O, blue C, white H) has been accomplished in eight linear steps starting from (R)-cryptone, which is readily available from eucalyptus oil. Key steps involve an asymmetric homoaldol reaction of chiral allyl carbamates and THF cyclocondensation. Ring-closing metathesis led to the tricyclic framework of the cladiellin diterpenes.
