1020073-95-3Relevant academic research and scientific papers
Regioselective Synthesis of α-Functional Stilbenes via Precise Control of Rapid cis- trans Isomerization in Flow
Lee, Hyune-Jea,Yonekura, Yuya,Kim, Nayoung,Yoshida, Jun-Ichi,Kim, Heejin
, p. 2904 - 2910 (2021)
The rapid cis-trans isomerization of α-anionic stilbene was regioselectively controlled by using flow microreactors, and its reaction with various electrophiles was conducted. The reaction time was precisely controlled within milliseconds to seconds at -50 °C to selectively give the cis- or trans-isomer in high yields. This synthetic method in flow was well-applied to synthesize precursors of commercial drug compound, (E)- and (Z)-tamoxifen with high regioselectivity and productivity.
Employing Water as the Hydride Source in Synthesis: A Case Study of Diboron Mediated Alkyne Hydroarylation
Rao, Santhosh,Joy, M. Nibin,Prabhu, Kandikere Ramaiah
, p. 13707 - 13715 (2018/11/30)
We present an approach to utilize water as the hydride source via Pd(II)/Pd(0) catalysis. As a case study, we have achieved a diboron mediated Pd(II)-catalyzed hydroarylation of alkynes using arylboronic acids. This approach not only complements conventional reactivity of Pd via Pd(0)/Pd(II) cycle for the hydroarylation but also utilizes water as the hydride source. We believe this would particularly be beneficial in utilizing water as a reagent.
Straightforward iron-catalyzed synthesis of vinylboronates by the hydroboration of alkynes
Haberberger, Michael,Enthaler, Stephan
supporting information, p. 50 - 54 (2013/02/23)
An iron-catalyzed hydroboration of alkynes to produce vinylboronates has been examined. With a straightforward system composed of iron carbonyls and pinacolborane, good to excellent yields and chemoselectivities were achieved for a variety of alkynes. Cop
Palladium-catalyzed hydroarylation of alkynes with arenediazonium salts
Cacchi, Sandro,Fabrizi, Giancarlo,Goggiamani, Antonella,Persiani, Daniela
supporting information; experimental part, p. 1597 - 1600 (2009/04/10)
The palladium-catalyzed hydroarylation of arenediazonium tetrafluoroborates with alkynes in the presence of triphenylsilane affords stereoselectively hydroarylation products in moderate to high yields. The reaction tolerates a variety of substituents including keto, ester, cyano, and nitro groups and can be performed as a one-pot procedure generating the arenediazonium salt in situ. With ethyl phenylpropynoate as the starting alkyne, the hydroarylation affords ethyl (2)-2-arylcinnamates stereo- and regioselectively.
