10201-15-7Relevant academic research and scientific papers
CARBONYL GROUP STABILIZATION OF RADICALS: SOLVENT EFFECTS ON AZOALKANE DECOMPOSITION
Luedtke, Al,Meng, Kim,Timberlake, Jack W.
, p. 4255 - 4258 (2007/10/02)
The synthesis and rates of decomposition of bis(1,1-dimethyl-2-oxopropyl)diazene (2p) are described.A series of substituted azoalkanes is compared to four other systems measuring radical substituent effects.These correlations and a solvent polarity study indicate the lack of polar contributions in azo decompositions.
Specific Inhibitors in Vitamin Biosynthesis. Part 7. Syntheses of Blocked 7,8-Dihydropteridines via &α-Amino Ketones
Al-Hassan, Saiba S.,Cameron, Robert J.,Curran, Adrian W. C.,Lyall, William J. S.,Nicholson, Sydney H.,et al.
, p. 1645 - 1660 (2007/10/02)
The synthesis of 15 blocked 7,8-dihydropteridines is described in which the pyrazine ring is built from a derivative of an α-amino ketone.Three routes to the amino ketones based upon amino acids, nitrosyl chloride addition to alkenes, and nitro alcohols are discussed.The compounds synthesised are inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase , an enzyme in the pathway leading to dihydrofolate, and the inhibitory potencies of the compounds are discussed in the light of a hypothetical active site model for the enzyme.
Synthesis and Crystallography of 2,3,3,5,6,6-Hexamethyl-3,6-dihydropyrazine Hexahydrate and 3-Amino-3-methyl-2-butanone Hydrochloride
Klein, Cheryl L.,Majeste, Richard J.,Luedtke, Alan E.,Ray, Warren J.,Stevens, Edwin D.,Timberlake, Jack W.
, p. 1208 - 1211 (2007/10/02)
The X-ray crystal structures and chemical reactions of 2,3,3,5,6,6-hexamethyl-3,6-dihydropyrazine hexahydrate and 3-amino-3-methylbutanone hydrochloride are described.
Method of synthesis of pteridines
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, (2008/06/13)
A pharmaceutical formulation of a compound of formula (II') SPC1 wherein Y is a lower alkyl group, in association with a pharmaceutically acceptable carrier, as an antibacterial product, and methods involving the preparation and reductive cyclization of a compound of formula (IV) SPC2 wherein X is a lower alkyl group or a hydroxymethyl group.
