37557-72-5Relevant academic research and scientific papers
Specific Inhibitors in Vitamin Biosynthesis. Part 7. Syntheses of Blocked 7,8-Dihydropteridines via &α-Amino Ketones
Al-Hassan, Saiba S.,Cameron, Robert J.,Curran, Adrian W. C.,Lyall, William J. S.,Nicholson, Sydney H.,et al.
, p. 1645 - 1660 (2007/10/02)
The synthesis of 15 blocked 7,8-dihydropteridines is described in which the pyrazine ring is built from a derivative of an α-amino ketone.Three routes to the amino ketones based upon amino acids, nitrosyl chloride addition to alkenes, and nitro alcohols are discussed.The compounds synthesised are inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase , an enzyme in the pathway leading to dihydrofolate, and the inhibitory potencies of the compounds are discussed in the light of a hypothetical active site model for the enzyme.
AMIDOACETONE ENOLATE ANIONS: ALKYLATION AND MICHAEL REACTION
Hoye, Thomas R.,Duff, Steven R.,King, Rita S.
, p. 3433 - 3436 (2007/10/02)
The lithyum enolate derived from benzamidoacetone (1) can be regiospecifically alkylated at C(1) and stereospecifically added in conjugate fashion to cyclohexenone without resorting to protection of free NH.Comparison is made with alkylations of methyl hippurate.
Method of synthesis of pteridines
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, (2008/06/13)
A pharmaceutical formulation of a compound of formula (II') SPC1 wherein Y is a lower alkyl group, in association with a pharmaceutically acceptable carrier, as an antibacterial product, and methods involving the preparation and reductive cyclization of a compound of formula (IV) SPC2 wherein X is a lower alkyl group or a hydroxymethyl group.
