1020156-02-8

Basic information

• Product Name: D(+)-O,O-dibenzoyl tartarate of zopiclone
• Synonyms: D(+)-O,O-dibenzoyl tartarate of zopiclone
• CAS NO: 1020156-02-8
• Molecular Weight: 747.118
• Mol File: 1020156-02-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: D(+)-O,O-dibenzoyl tartarate of zopiclone(CAS DataBase Reference)
• NIST Chemistry Reference: D(+)-O,O-dibenzoyl tartarate of zopiclone(1020156-02-8)
• EPA Substance Registry System: D(+)-O,O-dibenzoyl tartarate of zopiclone(1020156-02-8)

Safety Data

• Hazardous Substances Data: 1020156-02-8(Hazardous Substances Data)

Upstream product

• 17026-42-5 O,O'-dibenzoyl-D-tartaric acid 
• 43200-80-2 zopiclon 

Downstream Products

• 144025-94-5 (R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate D-(+)-O,O'-dibenzoyltartaric acid salt 
• 144025-93-4 eszopiclone dibenzoyl-D-tartrate 
• 138680-08-7 (-)-Zopiclone 
• 138729-47-2 eszopiclone 

Relevant articles and documents

PROCESS FOR PREPARATION OF DEXTROROTATORY ISOMER OF 6-(5-CHLORO-PYRID-2-YI)-5-[(4-METHYL -1-PIPERAZINYL) CARBONYLOXY]-7-OXO-6,7-DIHYDRO-5H-PYRROLO [3,4-B] PYRAZINE (ESZOPICLONE)

Disclosed herein is the process for preparation of 6-(5-chloro-pyrid-2-yl)-5-[(4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo [3,4-b] pyrazine (Zopiclone), its resolution to get the dextrorotatory isomer of formula (I) substantially free of R (-) enantiomer and recovery of key raw material i.e. 6-(5-chloro pyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo [3,4-b] pyrazine from the R-isomer of Zopiclone followed by conversion of the recovered compound to get pure Eszopiclone (I) in high yield and high purity.