102016-17-1Relevant academic research and scientific papers
Application of the mild-condition phthalimidine synthesis with use of 1,2,3-1h-benzotriazole and 2-mercaptoethanol as dual synthetic auxiliaries. Effective synthesis of phthalimidines possessing a variety of substituents at 2-position
Takahashi, Ichiro,Kawakami, Teruki,Hirano, Etsushi,Kimino, Mako,Kamimura, Shigeki,Miwa, Takayuki,Tamura, Takanori,Tazaki, Ryo,Kitajima, Hidehiko,Hatanaka, Minoru,Isa, Kimio,Hosoi, Shinzo
, p. 557 - 571 (2016)
The mild-condition phthalimidine synthesis based on Mannich type 1:1 condensation reaction between o-phthalaldehyde with a variety of primary amines in the presence of excess 2-mercaptoethanol and 1,2,3-1H-benzotriazole as "dual synthetic auxiliaries" in MeCN for 13 h at room temperature afford 2-substituted phthalimidines (2,3-dihydroisoindol-1-one) in fair to good isolated yields.
Preparation of 2-substituted 1,3-bis(benzotriazol-1-yl)isoindolines by the double mannich conden-sation reaction of o-phthalaldehyde with primary amines in the presence of 1,2,3-1 h-benzotriazole
Takahashi, Ichiro,Tsuzuki, Mikio,Yokota, Hiroshi,Morita, Toshio,Kitajima, Hidehiko,Isa, Kimio
, p. 71 - 90 (1996)
The preparation of isoindolines (1,3-dihydro-2H-isoindoles) possessing two reactive centers as mixed aminals is investigated. In the double Mannich condensation reaction of o-phthalaldehyde with a variety of primary amines in the presence of 1,2,3-1H-benzotriazole (Bt-H) in MeCN, Bt-substituted isoindolines are obtained in fair to good yields when anilines are used as amines.
