Preparation of 2-substituted 1,3-bis(benzotriazol-1-yl)isoindolines by the double mannich conden-sation reaction of o-phthalaldehyde with primary amines in the presence of 1,2,3-1 h-benzotriazole

Article abstract of DOI:10.3987/COM-95-7219

The preparation of isoindolines (1,3-dihydro-2H-isoindoles) possessing two reactive centers as mixed aminals is investigated. In the double Mannich condensation reaction of o-phthalaldehyde with a variety of primary amines in the presence of 1,2,3-1H-benzotriazole (Bt-H) in MeCN, Bt-substituted isoindolines are obtained in fair to good yields when anilines are used as amines.