Heterocycles p. 71 - 90 (1996)
Update date:2022-08-22
Topics:
Takahashi, Ichiro
Tsuzuki, Mikio
Yokota, Hiroshi
Morita, Toshio
Kitajima, Hidehiko
Isa, Kimio
The preparation of isoindolines (1,3-dihydro-2H-isoindoles) possessing two reactive centers as mixed aminals is investigated. In the double Mannich condensation reaction of o-phthalaldehyde with a variety of primary amines in the presence of 1,2,3-1H-benzotriazole (Bt-H) in MeCN, Bt-substituted isoindolines are obtained in fair to good yields when anilines are used as amines.
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(1964)
