1020192-38-4Relevant academic research and scientific papers
Design and synthesis C6-C8 bridged epothilone a
Zhan, Weiqiang,Jiang, Yi,Brodie, Peggy J.,Kingston, David G. I.,Liotta, Dennis C.,Snyder, James P.
, p. 1565 - 1568 (2008)
A conformationally restrained epothilone A analogue (3) with a short bridge between methyl groups at C6 and C8 was designed and synthesized. Preliminary biological evaluation indicates 3 to be only weakly active (IC50 = 8.5 μM) against the A2780 human ovarian cancer cell line.
