1020192-65-7Relevant academic research and scientific papers
Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1
Castellano, Sabrina,Kuck, Dirk,Sala, Marina,Novellino, Ettore,Lyko, Frank,Sbardella, Gianluca
, p. 2321 - 2325 (2008/12/22)
Constrained analogues of procaine were synthesized, and their inhibiting activity against DNMT1 was tested. Among them, the most potent compound, derivative 3b, was also able to induce a recognizable demethylation of chromosomal satellite repeats in HL60 human myeloid leukemia cells and thus represents a lead compound for the development of a novel class of non-nucleoside DNMT1 inhibitors.
