1020257-75-3Relevant academic research and scientific papers
Macrocyclic cysteine protease inhibitors and compositions thereof
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Page/Page column 99, (2016/09/26)
The present invention provides a novel class of macrocyclic compounds, which are useful as cysteine protease inhibitors. Also provided are novel intermediates and methods of preparing the compounds. The invention also provides pharmaceutical compositions
Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors
Abell, Andrew D.,Jones, Matthew A.,Coxon, James M.,Morton, James D.,Aitken, Steven G.,McNabb, Stephen B.,Lee, Hannah Y.-Y.,Mehrtens, Janna M.,Alexander, Nathan A.,Stuart, Blair G.,Neffe, Axel T.,Bickerstaffe, Roy
supporting information; experimental part, p. 1455 - 1458 (2009/07/25)
The design and elaboration of a series of macrocyclic templates that exhibit a propensity to adopt a β-strand-like peptide-backbone conformation led to potent and selective inhibitors of calpain 2. Macrocycle 1 retarded calcium-induced opacification in an
