10204-66-7

Usage

Uses

Used in Pharmaceutical Research:
(3beta,5beta,14beta,17beta)-3-(acetyloxy)-14-hydroxyandrostane-17-carboxylic acid is used as a research compound for exploring its potential biological activities and applications in the pharmaceutical industry. Its unique structural features and steroidal nature make it a promising candidate for further investigation into its therapeutic properties and possible uses in drug development.
Used in Drug Development:
In the field of drug development, (3beta,5beta,14beta,17beta)-3-(acetyloxy)-14-hydroxyandrostane-17-carboxylic acid is utilized as a starting material or intermediate for the synthesis of various steroidal drugs. Its specific functional groups and molecular structure allow for targeted modifications and the creation of new compounds with potential therapeutic benefits.
Used in Hormone Therapy:
(3beta,5beta,14beta,17beta)-3-(acetyloxy)-14-hydroxyandrostane-17-carboxylic acid may also be used as a component in hormone therapy, particularly for conditions that require the modulation of androgen levels. Its steroidal structure and functional groups make it a candidate for the development of treatments for hormonal imbalances and related health issues.

Upstream product

• 5041-06-5 uzarigenin 3-acetate 
• 26646-89-9 3β-Acetoxy-14-hydroxy-5β,14β-androstan-17β-carbaldehyd 
• 24533-02-6 14,21-Dihydroxy-20-oxo-5β,14β-pregnan-3β-yl-acetat 
• 808-19-5 digitoxigenin 3-acetate 
• 53297-44-2 3β-Acetoxy-20-oxo-5β,14β-pregnan-21,14-lacton 
• 26623-73-4 3β,14β-dihydroxy-5β-androstane-17β-carboxaldehyde 
• 26623-72-3 5β,14β-Pregnan-3β,14,20ξ,21-tetraol 
• 42516-41-6 14-hydroxy-3β-acetoxy-21-oxoacetyloxy-5β.14β-pregnanone-(20) 
• 64-19-7 acetic acid 
• 24533-02-6 14.21-dihydroxy-3β-acetoxy-5α.14β-pregnanone-(20) 

Downstream Products

• 2900-98-3 3β-acetoxy-14-hydroxy-5α,14β-androstane-17β-carboxylic acid methyl ester 
• 2900-98-3 3β-Acetoxy-14-hydroxy-5β,14β-androstan-17β-carbonsaeuremethylester 
• 10005-75-1 3β-Acetoxy-14-hydroxy-5β,14β-pregnan-20-on 

Relevant academic research and scientific papers

Partial Synthesis of Cardenolides and Cardenolide Analogues. XI. Synthesis of 3-(3&β,14-Dihydroxy-5&β,14&β-androstan-17&β-yl-methyl)but-2-en-4-olide, a Homologous 5&β,14&β-Cardenolide

Wittig reaction of 3β,14-dihydroxy-5β,14β-androstane-17β-carboxaldehyde 4 with 2-carboxy-1-ethoxycarbonyl-ethyl-triphenylphosphorane 11 followed by the reduction of the resulting half ester 5 and cyclization of the γ-hydroxy acid 6 yields the 3-alkylidenebutan-4-olide 8a which was isomerized to the 3-(steroidylmethyl)but-2-en-4-olide 9.Insertion of the methylene group between the steroidyl moiety and the but-2-en-4-olide ring strongly reduces the biological activity.

Partial Syntheses of Cardenolides and Cardenolide Analogues. X. Synthesis of 22-O-Substituted Cardenolides and Studies on the Oxidative Degradation of Cardenolides with Potassium Permanganate

The stereoisomeric 20,22-dihydroxy-cardanolides 2a and 3a as well as the oxalic acid half ester of the 3β-acetoxy-14,21-dihydroxy-5β,14β-pregnan-20-one (4a) and 3β-acetoxy-20-oxo-5β,14β-pregnane-21,14-lactone (5) were identified as intermediates of intermediates of oxidative degradation of digitoxigenin 3-acetate with potassium permanganate. 2a and 3a, after selective acylation in 22-position, were converted to the 22-acyloxy-cardenolides 7a and 7b via dehydration or acetoxyelimination after selective acetylation of the 20-hydroxy group.Saponification of both 7a and 7b yields the very stable 22-hydroxycardenolide 8a.The molecular biological activities of the 22-substituted cardenolides were investigated and discussed.