1020418-01-2Relevant academic research and scientific papers
Asymmetric hydrogenation of aromatic, aliphatic, and α,β- unsaturated acyl silanes catalyzed by tol-binap/pica ruthenium(II) complexes: Practical synthesis of optically active α-hydroxysilanes
Arai, Noriyoshi,Suzuki, Ken,Sugizaki, Satoshi,Sorimachi, Hiroko,Ohkuma, Takeshi
supporting information; scheme or table, p. 1770 - 1773 (2009/02/06)
(Chemical Equation Presented) A catalytic system of RuII complex (see scheme; Ar = 4-CH3C6H4; R = H, t-C 4H9) and t-C4H9OK or NaBH 4 activator has been used in the hydrogenation of aromatic and aliphatic acyl silanes to give α-hydroxysilanes with high enantioselectivity (R1 = aryl, alkyl, alkenyl; R2 = t-C4H9, C6H5). Optically active allylic α-hydroxysilanes are obtained in the 1,2-reduction of α,β-unsaturated acyl silanes. These chiral α-hydroxysilanes are converted into 4-substituted 2-cyclopentenones without loss of enantioselectivity.
