882882-36-2

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 639085-54-4 [(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)dichloromethyl]dimethylphenylsilane 
• 3839-31-4 dimethyl(phenyl)silyl lithium 
• 22342-18-3 1-morpholinopentan-1-one 
• 57733-85-4 (dichloromethyl)dimethyl(phenyl)silane 

Downstream Products

• 1020418-01-2 (R)-1-dimethylphenylsilyl-1-pentanol 

Relevant academic research and scientific papers

Stereoselective TiCl4-mediated aldol reactions starting from acylsilanes

A simple and efficient method for the preparation of β-hydroxyacylsilanes has been developed through a TiCl4-mediated aldol reaction. A selection of Lewis acids has been assessed, and other parameters such as solvent and temperature have been optimized. These aldol reactions occur under mild conditions and furnish a selection of β-hydroxy acylsilanes in fair-to-good yields with high syn selectivities (up to 99%).

Oxidation of gem-borylsilylalkylcoppers to acylsilanes with air

1-Boryl-1-silylalkylcoppers react with molecular oxygen in the presence of pyridine to afford acylsilanes efficiently. The one-pot process consists of two reactions: alkylation of 1-boryl-1-chloro-silylmethyllithium with Grignard reagents in the presence of copper(I) cyanide and aerobic oxidation of the alkylcopper species. This procedure enables us to access the divergent synthesis of acylsilanes.