102046-00-4

Upstream product

• 83948-28-1 N-(trimethylsilyl)cinnamaldimine 
• 96735-59-0 (S)-3-((R)-1-Hydroxy-ethyl)-4-((E)-styryl)-azetidin-2-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 101977-77-9 <3S,4S(E)>-3-<1(S)-hydroxyethyl>-1-(4-methoxyphenyl)-4-(2-phenylethenyl)-2-azetidinone 
• 80542-40-1 N-cinnamylidene-p-anisidine 
• 101977-83-7 (1'S,3S,4S)-3-(1'-<(tert-butyldimethylsilyl)oxy>ethyl)-1-(4'-methoxyphenyl)-4-(2'-phenylethenyl)-2-azetidinone 
• 96735-59-0 (S)-3-((S)-1-Hydroxy-ethyl)-4-((E)-styryl)-azetidin-2-one 
• 96735-60-3 Formic acid (R)-1-[(S)-2-oxo-4-((E)-styryl)-azetidin-3-yl]-ethyl ester 

Downstream Products

• 59995-64-1 thienamycin 

Relevant academic research and scientific papers

AN ENANTIOSELECTIVE APPROACH TO CARBAPENEM ANTIBIOTICS: FORMAL SYNTHESIS OF (+)-THIENAMYCIN

An enantioselective synthesis of intermediates in synthesis of thienamycin (15) and epithienamycin-C (16) is described.

Stereocontrolled total synthesis of the chiral building block (3S,4R)-3-[(R)-1-hydroxyethyl]-4-acetyloxy-azetidin-2-one: A useful synthon for the synthesis of (+)-thienamycin, carbapenems and penems

A total stereocontrolled synthesis of (1), an intermediate in the synthesis of (+)-thienamycin, carbapenems and penems, based on a strategy that uses the S(-)hydroxyethylbutyrate as chiral building block, is reported.