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Usage

Uses

Used in Pharmaceutical Applications:
(4-tert-butylphenyl)(fluoro)acetic acid is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. The modification of fluoroacetic acid with the (4-tert-butylphenyl) group may provide new properties that can be exploited in the development of drugs with specific therapeutic applications.
Used in Agricultural Applications:
(4-tert-butylphenyl)(fluoro)acetic acid may be used as a component in the development of new pesticides or as a modification to existing ones. The altered properties due to the (4-tert-butylphenyl) group could potentially enhance the effectiveness of the compound in controlling pests or reduce its environmental impact.
Used in Materials Science:
(4-tert-butylphenyl)(fluoro)acetic acid could be utilized in the development of new materials with specific properties. (4-tert-butylphenyl)(fluoro)acetic acid's unique structure may contribute to the creation of materials with enhanced characteristics for various industrial applications.
Further research is necessary to fully understand the properties and potential applications of (4-tert-butylphenyl)(fluoro)acetic acid in these and other fields.

Upstream product

• 124-38-9 carbon dioxide 
• 114467-73-1 1-(difluoromethyl)-4-(1,1-dimethylethyl)benzene 
• 32857-63-9 4-t-butylphenylacetic acid 
• 1234908-26-9 ethyl 2-(4-tert-butylphenyl)-2-fluoroacetate 
• 123324-71-0 p-tert-butylphenylboronic acid 

Relevant academic research and scientific papers

Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride

Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation.

Silver-Mediated 18F-Labeling of Aryl-CF3 and Aryl-CHF2 with 18F-Fluoride

We report the synthesis of [18F]arylCF3 and [18F]arylCHF2 derivatives from arylCF2Br and arylCHFCl precursors applying a silver-mediated halogen exchange with [18F]fluoride. In the absence of Ag(I)OTf, no reaction takes place at room temperature for both classes of substrates; this result demonstrates the beneficial role of silver(I) as a means to induce 18F-incorporation under very mild conditions.

Electrochemical carboxylation of α,α-difluorotoluene derivatives and its application to the synthesis of α-fluorinated nonsteroidal anti-inflammatory drugs

Electrochemical carboxylation of α,α-difluorotoluene derivatives resulted in an efficient fixation of carbon dioxide to give the corresponding α-fluorophenylacetic acids in good yields, and this reaction was successfully applied to the synthesis of α-fluorinated nonsteroidal anti-inflammatory drugs (NSAIDs). Georg Thieme Verlag Stuttgart.