1020538-07-1Relevant academic research and scientific papers
Design, synthesis, and biological testing of 4β-[(4-substituted)-1,2, 3-triazol-1-yl]podophyllotoxin analogues as antitumor agents
Reddy, Pitta B.,Paul, David V.,Agrawal, Satyam K.,Saxena, Ajit K.,Kumar, Halmuthur M. S.,Qazi, Ghulam N.
, p. 126 - 131 (2008)
A series of 4β-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin analogues have been synthesized with high regio-selectivity by employing copper(I)-catalyzed 1,3-dipolar cycloaddition of 1-O-propargyl monosaccharides with C4β-azido podophyllotoxin and C4β-azido-4′-O-demethyl podophyllotoxin. All the compounds were evaluated for their anticancer activity against a panel of six human cancer cell lines. Among these, 4′-O-demethyl podophyllotoxin congeners are showing promising anticancer activity mainly against HCT-15 (colon) and DU-145 (prostate) cells.
