1020667-77-9

Upstream product

• 1020667-78-0 4-methyl-6,7-(methylenedioxy)-9-[(3,4,5-trimethoxyphenyl)imino]-4,9-dihydrofuro[3,4-b]quinolin-1(3H)-one 
• 1020667-83-7 4-methyl-6,7-(methylenedioxy)-1-oxo-9-[(3,4,5-trimethoxyphenyl)amino]-1,3-dihydrofuro[3,4-b]quinolin-4-ium trifluoromethanesulfonate 

Relevant academic research and scientific papers

Design and effective synthesis of the first 4-aza-2,3- didehydropodophyllotoxin rigid aminologue: A N-methyl-4-[(3,4,5- trimethoxyphenyl)amino]-1,2-dihydroquinoline-lactone

(Chemical Equation Presented) The first N1-alkyl-4-amino-1,2- dihydroquinoline-lactone has been prepared by a five-step sequence in a 51% overall yield via the corresponding furo[3,4-b]quinolin-1(3H)-one. A new practical synthesis of this intermediate was carried out using versatile, commercially available starting materials and constitutes the shortest and highest yielding route. These synthetic pathways could be widened with a view toward the preparation of different substituted derivatives, which could be considered as rigid aminologues of 4-aza-2,3-didehydropodophyllotoxins.