1020719-86-1

Usage

Uses

Used in Pharmaceutical Industry:
Sulfamethoxazole D4 (benzene D4) is used as a research compound for studying the mechanisms of action and resistance development in bacteria. Its isotopically labeled nature allows for detailed analysis of its interactions with bacterial enzymes and the effects of its inhibition on bacterial growth and survival.
Used in Antimicrobial Applications:
Sulfamethoxazole D4 (benzene D4) is used as an antimicrobial agent for the treatment of various bacterial infections. It is particularly effective against gram-negative and gram-positive bacteria, making it a versatile choice for a wide range of infections.
Used in Drug Development:
In the field of drug development, Sulfamethoxazole D4 (benzene D4) serves as a valuable tool for the design and optimization of new antibiotics. Its structure and mechanism of action can be used as a starting point for the development of novel compounds with improved efficacy, selectivity, and reduced potential for resistance development.
Used in Diagnostic Applications:
Sulfamethoxazole D4 (benzene D4) can be employed in diagnostic applications to detect and monitor bacterial infections. Its isotopically labeled nature allows for the sensitive detection of bacterial growth and the effectiveness of antibiotic treatments in clinical settings.
Used in Research and Development:
Sulfamethoxazole D4 (benzene D4) is used as a research tool in the study of bacterial metabolism, enzyme inhibition, and the development of antibiotic resistance. It can also be used to investigate the structure-activity relationships of sulfonamide antibiotics and to identify potential new targets for antimicrobial drug development.

Upstream product

• 4165-60-0 nitrobenzene-d5 
• 1076-43-3 benzene-d6 
• 77435-44-0 p-acetamidobenzenesulfonyl chloride-d₄ 
• 15826-91-2 acetanilide-d5 
• 4165-61-1 aniline-d5 

Relevant academic research and scientific papers

Stable isotope labeled sulfamethoxazole and synthesis method thereof

The invention discloses stable isotope labeled sulfamethoxazole and a synthesis method thereof. The synthesis method comprises following steps: S1, stable isotope labeled aniline and acetic anhydrideare subjected to a reaction, and stable isotope labeled acetaminobenzene is prepared; S2, stable isotope labeled acetaminobenzene and chlorosulfonic acid are subjected to a reaction, and stable isotope labeled p-acetamidobenzene sulfonyl chloride is prepared; S3, stable isotope labeled p-acetamidobenzene sulfonyl, 3-amino-5-methylisoxazole and 4-dimethylaminopyridine are subjected to a reaction, and stable isotope labeled acetylsulfamethoxazole is prepared; S4, stable isotope labeled acetylsulfamethoxazole is hydrolyzed under the alkaline condition, and stable isotope labeled sulfamethoxazoleis obtained. The synthesis process is simple, a product is easy to separate and purify, chemical purity and isotope abundance of the obtained product both reach 99% or higher, and the product meets the requirement of a standard reagent for quantitatively detecting sulfamethoxazole; stable isotope labeled sulfamethoxazole has high use value and good economic efficiency.

Stable isotope deuterium labeled sulfanilamide drug and preparation method thereof

The invention belongs to the technical field of chemical synthesis, and specifically relates to a stable isotope deuterium labeled sulfanilamide drug and a preparation method thereof. The preparationmethod comprises the following steps: (1) subjecting benzene-d6 (I) to a nitratlon reaction so as to prepare deuterium labeled nitrobenzene-d5 (II); (2) reducing nitro of the deuterium labeled nitrobenzene-d5 (II) so as to prepare deuterium labeled aniline-d5 (III); (3) under the conditions of anhydrous sodium acetate and glacial acetic acid, subjecting the deuterium labeled aniline-d5 (III) and acetic anhydride to a reaction so as to prepare deuterium labeled N-acetanilide-d5 (IV); (4) subjecting the deuterium labeled N-acetanilide-d5 (IV) and chlorosulfonic acid to a reaction so as to prepare deuterium labeled 1-chlorosulfonyl-4-acetamidobenzene-d4 (V); and (5) allowing R to substitute chlorine of the deuterium labeled 1-chlorosulfonyl-4-acetamidobenzene-d4 (V), and carrying out hydrolysis so as to prepare an isotope deuterium labeled sulfanilamide drug (VII). The preparation method provided by the invention has the advantages of simple reaction conditions, short reaction time, highconversion efficiency, strong economy, and applicability to mass synthesis.