1020726-47-9Relevant academic research and scientific papers
A facile synthesis of 1,3-dihydroisobenzofurans using iodocylization of 2-vinylbenzyl alcohols
Kobayashi, Kazuhiro,Shikata, Kazuaki,Fukamachi, Shuhei,Konishi, Hisatoshi
, p. 599 - 609 (2008/09/20)
An efficient route for the preparation of 1,3-dihydroisobenzofurans based on the iodine-mediated cyclization of 2-vinylbenzyl alcohols, which can be prepared feasibly by reactions of 2-vinylphenyllithiums with carbonyl compounds, is reported. Substitution reactions of the iodo moiety of the resulting 1-(iodomethyl)-1,3-dihydroisobenzofurans with tributyltin hydride and sodium thiolates are also described.
