102081-79-8

Basic information

• Product Name: diethyl 2,2'-[carbonylbis(azanediyl)]dibenzoate
• Synonyms: diethyl 2,2'-[carbonylbis(azanediyl)]dibenzoate
• CAS NO: 102081-79-8
• Molecular Weight: 356.378
• Mol File: 102081-79-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl 2,2'-[carbonylbis(azanediyl)]dibenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2,2'-[carbonylbis(azanediyl)]dibenzoate(102081-79-8)
• EPA Substance Registry System: diethyl 2,2'-[carbonylbis(azanediyl)]dibenzoate(102081-79-8)

Safety Data

• Hazardous Substances Data: 102081-79-8(Hazardous Substances Data)

Upstream product

• 2306-33-4 monoethyl phthalate 
• 85-44-9 phthalic anhydride 
• 75-44-5 phosgene 
• 87-25-2 2-ethoxycarbonylaniline 

Downstream Products

• 1029791-08-9 ethyl 2-[2,4-dioxo-1,2-dihydroquinazoline-3(4H)-yl]benzoate 
• 1701-95-7 3-(2-Carboxyphenyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione 

Relevant articles and documents

Synthesis of New Dialkyl 2,2′-[Carbonyl bis (azanediyl)]dibenzoates via Curtius Rearrangement

The 2-(alkylcarbonyl)benzoic acids obtained by esterification of phthalic anhydride are converted into azide derivatives: alkyl 2-[(azidocarbonyl)amino]benzoates and to ureas: dialkyl 2,2′-[carbonyl bis (azanediyl)]dibenzoates. These transformations were carried out using classical Curtius rearrangement conditions in the presence of diphenylphosphoryl azide (DPPA) in a basic medium, followed by hydrolysis. Subsequently, a final condensation reaction of these urea derivatives enabled us to obtain, for the first time, the new alkyl derivatives, alkyl 2-[2,4-dioxo-1,2-dihydroquinazolin-3(4 H)-yl]benzoates. All the new compounds obtained in satisfactory yields were characterized by 1H and 13C NMR, and by X-ray crystallographic analysis.