1020849-56-2Relevant academic research and scientific papers
Palladium-catalyzed cyclization/heck- and cyclization/conjugate-addition- type sequences in the preparation of polysubstituted furans
Aurrecoechea, Jose M.,Durana, Aritz,Perez, Elena
, p. 3650 - 3653 (2008/09/20)
(Chemical Equation Presented) Palladium-catalyzed heterocyclization- coupling sequences have been developed starting from buta-1,2,3-trienyl carbinols and electron-deficient alkenes. Polysubstituted furans are formed where the heterocyclic ring originates from the elements of the butatrienyl carbinol while the electron-deficient olefin is incorporated as a C-3 substituent. In most cases, the reaction proceeds via a Heck-type pathway leading to the efficient formation of 3-vinylfurans. However, couplings with methyl vinyl ketone display a divergent behavior to afford selectively either Heck- or hydroarylation-type products depending on reaction conditions.
