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78-94-4 Usage

Chemical Description

Methyl vinyl ketone (MVK) is a colorless liquid with a pungent odor.

Chemical Description

Methyl vinyl ketone is an organic compound with the formula CH3C(O)CH=CH2.


Methyl vinyl ketone (MVK) is a stable, highly flammable, heat and light-sensitive, and colorless liquid. It is a reactive organic compound classified as an enone, with a pungent odor and is easily soluble in water, methanol, ethanol, and acetic acid. Its alkylating ability is both the source of its high toxicity and the feature that makes it a useful intermediate in organic synthesis.


Used in Chemical Synthesis:
Methyl vinyl ketone is used as an alkylating agent for its ability to transfer alkyl groups to other molecules, making it a valuable intermediate in various chemical reactions.
Used in Plastics Industry:
MVK is used as a commercial starting material for the production of plastic polymers, taking advantage of its tendency to polymerize spontaneously.
Used in Pharmaceutical Industry:
Methyl vinyl ketone serves as an intermediate in the synthesis of steroids and vitamin A, contributing to the development of essential medications and supplements.
Used in Organic Synthesis:
Due to its reactivity and alkylating ability, MVK is utilized as a versatile intermediate in organic synthesis, enabling the creation of a wide range of compounds for various applications across different industries.

Air & Water Reactions

Highly flammable. Miscible with water. Unstable in the presence of heat, light and air.

Reactivity Profile

Methyl vinyl ketone is incompatible with strong oxidizers and strong bases. Methyl vinyl ketone polymerizes spontaneously upon exposure to heat or sunlight. This polymerization may cause violent ruptures in containers. .

Health Hazard

Methyl vinyl ketone is readily absorbed through the skin, causing general poisoning, similar to other ketones; inhalation has central nervous system depressant effects. It is irritating to mucous membranes and respiratory tract and to the skin; it is a lachrymator and can cause eye injury.

Fire Hazard

Vapors form flammable mixtures with air, and may travel a considerable distance to a source of ignition and flash back. Polymerization may take place in containers, possibly with violent rupture of containers. Upon exposure to heat or flame, Methyl vinyl ketone emits toxic and irritating fumes. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors, or in sewers. Polymerizes on standing. Hazardous polymerization may occur. Avoid heat or sunlight.

Safety Profile

Poison by ingestion, inhalation, and intraperitoneal routes. A severe irritant to skin, eyes, and mucous membranes. A lachrymator. Mutation data reported. See also KETONES. Dangerous fire hazard when exposed to heat, flame, or oxidizers. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes.

Potential Exposure

Methyl vinyl ketone is used as an alkylating agent, a starting material for plastics; and an intermediate in the synthesis of steroids and Vitamin A.


UN1251 Methyl vinyl ketone, stabilized, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, 8-Corrosive material, Inhalation Zone A.

Purification Methods

It forms an 85% azeotrope with water. After drying with K2CO3 and CaCl2 (with cooling), the ketone is distilled at low pressures. [Beilstein 1 IV 3444.]


Vapors may form explosive mixture with air. Heat or shock may cause explosive polymerization. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrated amines, azo, diazo, azido compounds, carbamates, organic cyanates.

Check Digit Verification of cas no

The CAS Registry Mumber 78-94-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 78-94:
74 % 10 = 4
So 78-94-4 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name buten-2-one

1.2 Other means of identification

Product number -
Other names but-3-en-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78-94-4 SDS

78-94-4Relevant articles and documents

Reactivity of Ionic Liquids: Reductive Effect of [C4C1im]BF4 to Form Particles of Red Amorphous Selenium and Bi2Se3 from Oxide Precursors

Knorr, Monika,Schmidt, Peer

, p. 125 - 140 (2020/12/17)

Temperature-induced change in reactivity of the frequently used ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([C4C1im]BF4) is presented as a prerequisite for the rational screening of reaction courses in material synthesis. [C4C1im]BF4 becomes active with oxidic precursor compounds in reduction reaction at ?≥200 °C, even without the addition of an external reducing agent. The reaction mechanism of forming red amorphous selenium from SeO2 is investigated as a model system and can be described similarly to the Riley oxidation. The reactive species but-1-ene, which is formed during the decomposition of [C4C1im]BF4, reacts with SeO2 and form but-3-en-2-one, water, and selenium. Elucidation of the mechanism was achieved by thermoanalytical investigations. The monotropic phase transition of selenium was analyzed by the differential scanning calorimetry. Beyond, the suitability of the single source oxide precursor Bi2Se3O9 for the synthesis of Bi2Se3 particles was confirmed. Identification, characterization of formed solids succeeded by using light microscopy, XRD, SEM, and EDX.

Iridium-Catalyzed Hydrochlorination and Hydrobromination of Alkynes by Shuttle Catalysis

Yu, Peng,Bismuto, Alessandro,Morandi, Bill

supporting information, p. 2904 - 2910 (2020/01/25)

Described herein are two different methods for the synthesis of vinyl halides by a shuttle catalysis based iridium-catalyzed transfer hydrohalogenation of unactivated alkynes. The use of 4-chlorobutan-2-one or tert-butyl halide as donors of hydrogen halides allows this transformation in the absence of corrosive reagents, such as hydrogen halides or acid chlorides, thus largely improving the functional-group tolerance and safety profile of these reactions compared to the state-of-the-art. This method has granted access to alkenyl halide compounds containing acid-sensitive groups, such as tertiary alcohols, silyl ethers, and acetals. The synthetic value of those methodologies has been demonstrated by gram-scale synthesis where low catalyst loading was achieved.

TBN-Catalyzed Dehydrative N-Alkylation of Anilines with 4-Hydroxybutan-2-one

Cheng, Wenchen,Deng, Shue,Jiang, Liya,Ren, Lanhui,Wang, Zicheng,Zhang, Jian,Song, Weiguo

, p. 7372 - 7377 (2019/11/28)

Until now, the substitution of alcohols by N-nucleophiles via TBN-catalyzed dehydrogenation was not known. Herein, we reported a TBN catalyzed dehydrative N-alkylation of anilines with 4-hydroxybutan-2-one in the presence of TEMPO, which was different from the TEMPO/TBN catalyzed oxidation reactions. A range of anilines reacted successfully with 4-hydroxybutan-2-one to generate the N-monoalkylation products in good yields. Mechanistic studies revealed that this reaction most possibly proceeded through aza-Michael addition. Water was the only by-product, making it more environmentally friendly. The gram-scale reactions verified the synthetic practicality of this protocol.