1021096-70-7

Basic information

• Product Name: 5-amino-2-[(4-fluorophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione
• Synonyms: 5-amino-2-[(4-fluorophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione
• CAS NO: 1021096-70-7
• Molecular Weight: 270.263
• Mol File: 1021096-70-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-amino-2-[(4-fluorophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-2-[(4-fluorophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione(1021096-70-7)
• EPA Substance Registry System: 5-amino-2-[(4-fluorophenyl)methyl]-2,3-dihydro-1H-isoindole-1,3-dione(1021096-70-7)

Safety Data

• Hazardous Substances Data: 1021096-70-7(Hazardous Substances Data)

Upstream product

• 3676-85-5 4-aminophthalimide 
• 459-46-1 4-Fluorobenzyl bromide 
• 136918-14-4 phthalimide 
• 337474-19-8 2-(4-fluorobenzyl)-5-nitro-1H-isoindole-1,3(2H)-dione 
• 89-40-7 4-nitrophthalimide 

Downstream Products

• 1428332-78-8 C₂₂H₁₇FN₂O₄S 

Relevant articles and documents

Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor

Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan. MMP-7 is a validated target for the development of small molecule drugs against cancer. MMP-13 is within the enzyme class the most efficient contributor to type II collagen degeneration and is a validated target in arthritis and cancer. We have developed the dual MMP-7/-13 inhibitor ZHAWOC6941 with IC50-values of 2.2 μM (MMP-7) and 1.2 μM (MMP-13) that is selective over a broad range of MMP isoforms. It spares MMP-1, -2, -3, -8, -9, -12 and -14, making it a valuable modulator for targeted polypharmacology approaches.