3676-85-5Relevant articles and documents
Development of three ways molecular logic gate based on water soluble phenazine fluorescent ‘selective ion’ sensor
Daniel Thangadurai,Nithya,Rakkiyanasamy
, p. 132 - 140 (2019)
New hydrophilic fluorescent selective ion sensor based on phenazine and phthalazine moieties, 1,1′-(phenazine-2,3-diyl)-bis(3-(1,4-dihydroxyphthalazin-6-yl)urea) (1), has been designed, synthesized and characterized. Interestingly, sensor 1 exhibits prominent “turn-on” and “turn-off” fluorogenic signaling at 580 nm towards Fe2+ & AcO? and Sr2+ & Cu2+, respectively. The fluorescence titration experiments shed light on the nature of the interaction between 1 and guest molecules (Fe2+, Sr2+, Cu2+ and AcO?), which divulge that 1 is flexible enough to orient itself according to the size of the guest molecule. Water mediated excited-state intramolecular proton transfer (ESIPT) and photo-induced electron transfer (PET) mechanisms are responsible for the dual behavior of 1, which binds with guest molecules in 1:1 stoichiometry. Based on the significant duplex fluorescence response of 1, a molecular logic gate keypad lock with sixteen “on” passwords for a storage system has been developed.
Phthalimide compound as well as preparation method and application thereof
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Paragraph 0076; 0080-0081, (2021/06/09)
The invention provides a phthalimide compound or a pharmaceutically acceptable salt thereof, wherein the structure of the phthalimide compound is shown as a formula I; in the formula I, R1 is selected from hydrogen, aliphatic hydrocarbon, alkoxy and halogen; R2 and R3 are the same or different and are selected from hydrogen, aliphatic hydrocarbon, alkoxy and halogen; or R2, R3 and connected N atoms are cyclized to form a closed substituted or unsubstituted five-membered or six-membered ring; R1, R2 and R3 can be unsubstituted or substituted by straight chain or branched chain alkyl or alkoxy selected from C1 - C10 and halogen; and R1, R2 and R3 are not hydrogen at the same time. The compound disclosed by the invention has the effect of a ROCK inhibitor and an anti-tumor effect, and is expected to be used as a clinical medicine with a relatively high therapeutic index.
Mechanochemical catalytic transfer hydrogenation of aromatic nitro derivatives
Portada, Tomislav,Margeti?, Davor,?trukil, Vjekoslav
supporting information, (2018/12/11)
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields.
