1021189-98-9Relevant academic research and scientific papers
Total synthesis of the C-1027 chromophore core: Extremely facile enediyne formation through SmI2-mediated 1,2-elimination
Inoue, Masayuki,Ohashi, Isao,Kawaguchi, Teruko,Hirama, Masahiro
supporting information; scheme or table, p. 1777 - 1779 (2009/02/06)
(Chemical Equation Presented) The spontaneous aromatization of the enediyne chromophore of the potent antitumor agent C-1027 generates a p-benzyne biradical, which cleaves double-stranded DNA. The title reaction was developed for the construction of nine-membered-ring enediynes and applied as the final step in the synthesis of the exceptionally unstable core structure of the C-1027 chromophore (see scheme; Boc, MOM, MPM, and TES are protecting groups; Ms=methanesulfonyl).
