Welcome to LookChem.com Sign In|Join Free
  • or
β-D-arabinofuranosyl-5-methylisocytosine, also known as 5-methylcytosine arabinoside or Ara-C, is a nucleoside analog that plays a significant role in the field of chemotherapy. It is a synthetic derivative of the naturally occurring nucleoside cytidine, with a key difference being the presence of a methyl group at the 5-position of the cytosine base. This modification enhances the drug's ability to inhibit DNA synthesis, making it an effective antiviral and anticancer agent. Ara-C is primarily used to treat certain types of leukemia, such as acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), by incorporating itself into the DNA of rapidly dividing cancer cells and halting their replication. Its mechanism of action involves being phosphorylated by cellular enzymes to form Ara-CTP, which then competes with the natural nucleoside triphosphates, leading to DNA strand termination and ultimately cell death. Due to its specific activity against rapidly dividing cells, Ara-C is also used in the treatment of some viral infections, although its use in this context is more limited.

10212-31-4

Post Buying Request

10212-31-4 Suppliers

Recommended suppliers

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

10212-31-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 10212-31-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,1 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 10212-31:
(7*1)+(6*0)+(5*2)+(4*1)+(3*2)+(2*3)+(1*1)=34
34 % 10 = 4
So 10212-31-4 is a valid CAS Registry Number.

10212-31-4Downstream Products

10212-31-4Relevant academic research and scientific papers

Convenient synthesis of oligodeoxyribonucleotides bearing arabinofuranosyl pyrimidine derivatives and its duplex formation with complementary DNA

Ozaki, Hiroaki,Nakajima, Kiyohiro,Tatsui, Kaoru,Izumi, Chieko,Kuwahara, Masayasu,Sawai, Hiroaki

, p. 2441 - 2443 (2007/10/03)

The oligodeoxyribonucleotides bearing 2,2′-anhydro-β-D-arabinofuranosyluracil derivatives were synthesized and the modified residue was converted to β-D-arabinofuranosyluracil derivatives or β-D-arabinofuranosylisocytosine derivatives by post-synthetic modification method. The melting profiles of their ODNs with complementary DNA were studied.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 10212-31-4