102130-85-8

Basic information

• Product Name: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, phenylmethyl ester, (S)-
• CAS NO: 102130-85-8
• Molecular Formula: C19H18N2O2
• Molecular Weight: 306.364
• Mol File: 102130-85-8.mol

Chemical Properties

• CAS DataBase Reference: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, phenylmethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, phenylmethyl ester, (S)-(102130-85-8)
• EPA Substance Registry System: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, phenylmethyl ester, (S)-(102130-85-8)

Safety Data

• Hazardous Substances Data: 102130-85-8(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 42438-90-4 3-carboxy-1,2,3,4-tetrahydro-2-carboline 
• 50-00-0 formaldehyd 
• 22839-16-3 L-tryptophan benzyl ester hydrochloride 
• 22839-16-3 L-tryptophan benzyl ester hydrochloride 
• 100-51-6 benzyl alcohol 
• 73-22-3 L-Tryptophan 
• 66863-43-2 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid 

Downstream Products

• 479218-88-7 3S[2-Boc-Gln-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester 
• 479218-85-4 3S-[2-Boc-Ala-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester 
• 479218-90-1 3S[2-Boc-Gly-Arg(Tos)-Pro-Ala-Lys(ClZ)]-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester 

Relevant articles and documents

Indole-TEMPO conjugates alleviate ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function

Mitochondrial oxidative damage contributes to a wide range of pathologies including ischemia/reperfusion injury. Accordingly, protecting mitochondria from oxidative damage should possess therapeutic relevance. In the present study, we have designed and synthesized a series of novel indole-TEMPO conjugates that manifested good anti-inflammatory properties in a murine model of xylene-induced ear edema. We have demonstrated that these compounds can protect cells from simulated ischemia/reperfusion (s-I/R)-induced reactive oxygen species (ROS) overproduction and mitochondrial dysfunction. Furthermore, we have demonstrated that indole-TEMPO conjugates can attenuate organ damage induced in rodents via intestinal I/R injury. We therefore propose that the pharmacological profile and mechanism of action of these indole-TEMPO conjugates involve convergent roles, including the ability to decrease free radical production via lipid peroxidation which couples to an associated decrease in ROS-mediated activation of the inflammatory process. We further hypothesize that the protective effects of indole-TEMPO conjugates partially reside in maintaining optimal mitochondrial function.

Amino acid and amino n-hexanoic acid modified carboline carboxylic acid benzyl ester, preparation, activity and applications thereof

The invention discloses (3S)-N-(6-aminoamido-n-hexanoyl)-2,3,4,9-tetrahydro-beta-carboline-3-carboxylic acid benzyl ester having the following structure (AA in the formula is selected from L-Phe residue, L-Gly residue, L-Ile residue, L-Val residue and L-Tyr residue), a preparation method and antitumor applications thereof, and further relates to applications in preparation of antitumor drugs.

6 - Amino is amino hexanoyl Carboline carboxylic acid benzyl ester, its preparation, active and application (by machine translation)

The invention discloses the following structure (3 S) - N - (6 - amino is amino hexanoyl) - 2, 3, 4, 9 - tetrahydro - β - Carboline - 3 - carboxylic acid benzyl ester (in the formula AA is selected from L - Lys, L - Leu, L - Met, L - Asn, L - Pro, L - Ser, L - Thr and L - Trp residue). Discloses a process for their preparation and its anti-tumor effect, expounded in the preparation of anti-tumor effect in application. (by machine translation)

Glutamine amido n-hexanoyl carboline-3-carboxylic acid benzyl ester, preparation, activity and applications thereof

The invention discloses (3S)-N-(6-glutamine amido n-hexanoyl)-2,3,4,9-tetrahydro-beta-carboline-3-carboxylic acid benzyl ester having the following structure, a preparation method and antitumor applications thereof, and further relates to applications in preparation of antitumor drugs.

Side chain protected aminoamido n-hexanoyl carboline carboxylic acid benzyl ester, preparation, activity and applications thereof

The invention discloses (3S)-N-(6-aminoamido-n-hexanoyl)-2,3,4,9-tetrahydro-beta-carboline-3-carboxylic acid benzyl ester having the following structure (AA in the formula is selected from L-Asp (OBzl) residue, L-Glu (OBzl) residue and L-Arg (NO2) residue), a preparation method and antitumor applications thereof, and further relates to applications in preparation of antitumor drugs.

6-aminoacylamino n-hexanoyl carboline benzyl carboxylate, and preparation and application thereof

The invention discloses (3S)-N-(6-AA-amino-n-hexanoyl)-2,3,4,9-tetrahydro-beta-carbolin-3-benzyl carboxylate having the following structure described in the specification (wherein in the formula, AA is selected from L-Glu (OBzl) residue, L-Ile residue, L-Lys residue, L-Leu residue, L-Met residue, L-Pro residue and L-Ser residue), and a preparation method, an anti-tumor metastasis effect and an anti-inflammatory effect thereof, and an application thereof in preparation of anti-tumor metastasis drugs and anti-inflammatory drugs.

Benzyl glutamine aminohexyl carboline carboxylate, and preparation, activity and application thereof

The invention discloses benzyl (3S)-N-(6-Gln-amino-n-hexyl)-2,3,4,9-tetrahydro-beta-carbolin-3-carboxylate having the following structure described in the specification, and a preparation method and lung cancer metastasis resistance dose-dependent relationship thereof, an anti-inflammatory effect thereof, and an application thereof in preparation of anti-tumor metastasis drugs and anti-inflammatory drugs.

6-aminoacylamino n-hexanoyl carboline benzyl carboxylate, and preparation, activity and application thereof

The invention discloses (3S)-N-(6-AA-amino-n-hexanoyl)-2,3,4,9-tetrahydro-beta-carbolin-3-benzyl carboxylate having the following structure defined in the specification (wherein in the formula, AA isselected from Gly residue, L-Asn residue, L-Thr residue and L-Trp residue), and a preparation method and anti-tumor metastasis effect thereof, and an application thereof in preparation of anti-tumor metastasis drugs.

Design, synthesis, and evaluation of a novel class of 2,3-disubstituted- tetrahydro-β-carboline derivatives

Several novel tetrahydro-β-carboline derivatives with amino acid residues at the 2-position and a glucosamine group at the 3-position of the tetrahydro-β-carboline nucleus were synthesized from a readily available starting material, tryptophane, and were evaluated for their anti-inflammatory activity in the present study. Our results showed that all of the derivatives tested exhibited a significant inhibition of xylene-induced inflammation in mice.

Carboline-3-carboxylic acid modified related sequences of Ala-Arg-Pro-Ala-Lys, their synthesis and use as thromobolytic agent

The present invention relates to the protected intermediates and the deprotected products of P6A, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-(2-Boc)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid and the deprotected pseudopeptides, related to the protected pseudopeptides introducing the protected intermediateds of P6A to 3S-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid benzyl ester, related to the methods for their preparation, and related to their use as the thrombolytic agents.