102145-67-5

Upstream product

• 2555-29-5 8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one 
• 100-52-7 benzaldehyde 
• 2747-05-9 4-methylumbelliferyl acetate 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 108-46-3 recorcinol 
• 115664-84-1 7-Hydroxy-4-methyl-8-[(E)-(3-phenyl-acryloyl)]-chromen-2-one 

Relevant academic research and scientific papers

Microwave-assisted synthesis of 8-aryl-10-chloro-4-methyl-2-oxo-2,8-dihydropyrano[2,3-f]chromene-9-carbaldehydes and their antimicrobial activity

A series of new coumarin-chromene hybrids have been synthesized by conventional and microwave irradiation methods from 8-aryl-4-methyl-8,9-dihydropyrano[2,3-f]chromene-2,10-diones using the Vilsmeier-Haack reagent. All the synthesized compounds were chara

Synthesis and antiproliferative and c-Src kinase inhibitory activities of cinnamoyl-and pyranochromen-2-one derivatives

A series of 6-and 8-cinnamoylchromen-2-one and dihydropyranochromen-2-one derivatives were synthesized and their antiproliferative activities were evaluated against three human cancer cell lines, i.e., ovarian adenocarcinoma (SK-OV-3), leukemia (CCRF-CEM), and breast carcinoma (MCF-7). In general, 8-cinnamoylchromen-2-one derivatives were found to have higher antiproliferative activity against the cancer cells when compared with 6-cinnamoyl analogues. Among all of the hybrid chromen-2-one-chalcone/flavanone compounds, a 7-hydroxy-8-cinnamoylchromen-2-one derivative 35 was found to be consistently active against all the cancer cell lines and inhibited the cell proliferation of SK-OV-3, CCRF-CEM, and MCF-7 by 63%, 50%, and 43%, respectively, at a concentration of 50 μmol/L after 72 h of incubation. This compound also exhibited the highest Src kinase inhibition (IC50 = 14.5 μmol/L). Structure-activity relationship studies provided insights for designing the next generation of chromen-2-one-chalcone hybrid prototypes and the development of new leads as anticancer agents and (or) Src kinase inhibitors.

Synthesis of new α-pyronochalcones and related cyclisation products

Ten substituted α-pyronochalcones (I-X) and four α-pyronoflavanones (XI-XIV) have been obtained from 8-acetyl-7-hydroxy-4-methylcoumrin and characterised.The present data cast serious doubts in the claim in a recent publication on the synthesis of benzopy

Synthesis and Biological Properties of Substituted 2H-1-Benzopyran-2-ones and 2H,10H-Benzodipyran-2,10-diones

In continuation of our earlier studies in substituted pyrazoles, benzopyranopyrazoles, benzindazoles, benzcycloheptapyrazoles, pyrazoloquinolines and 2/4H-1-benzopyran-2/4-ones, which exhibit various biological activities, n