1021490-96-9

Upstream product

• 98-88-4 benzoyl chloride 
• 735326-98-4 phenyl 3-O-benzyl-4,6-O-benzylidene-1-thio-α-L-idopyranoside 
• 118711-49-2 1,2,4,6-tetra-O-acetyl-3-O-benzyl-L-idopyranoside 
• 158325-38-3 phenyl 2,4,6-tri-O-acetyl-3-O-benzyl-1-thio-α-L-idopyranoside 
• 108-98-5 thiophenol 

Downstream Products

• 1021490-97-0 phenyl 2-O-benzoyl-3,4-di-O-benzyl-1-thio-α-L-idopyranoside 
• 175978-41-3 phenyl 2-O-benzoyl-3-O-benzyl-4,6-dihydroxylthio-α-L-idopyranoside 
• 616876-73-4 methyl (phenyl 2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranoside)uronate 
• 1610791-08-6 C₄₂H₃₆O₉S 
• 1610791-13-3 methyl O-(methyl 2-O-benzoyl-3-O-benzyl-4-O-(4-(((9H-fluoren-9-yl)methoxy)carbonyloxy)-α-L-idopyranosyluronate)-(1→4)-2-azido-6-O-benzoyl-3-benzyl-2-deoxy-α-D-glucopyranoside) 
• 850637-33-1 phenyl 2-O-benzoyl-3-O-benzyl-1-thio-α-L-idopyranosyluronic acid 

Relevant academic research and scientific papers

Total synthesis of anticoagulant pentasaccharide fondaparinux

The anticoagulant pentasaccharide fondaparinux was synthesized using an improved and optimized synthetic strategy including a convergent [3+2] coupling approach, orthogonal protecting groups and various glycosyl donors. The new methods of glycosylation were also used for controlling the stereochemical configuration and improving the yield of the glycosylation. In addition, HPLC and NMR methods to monitor the process of total synthesis of fondaparinux were employed. This work provides a comprehensive elaboration for the synthesis and analysis of fondaparinux based on related literature, as well as abundant information for the synthesis of heparin-like oligosaccharides. A matter of protection! The anticoagulant pentasaccharide fondaparinux was synthesized using an improved and optimized synthetic strategy. The process of total synthesis was monitored by HPLC and NMR. This work will contribute to continued improvement of the multistep production of fondaparinux and provide abundant information for the synthesis of heparin-like oligosaccharides.

An efficient synthesis of l-idose and l-iduronic acid thioglycosides and their use for the synthesis of heparin oligosaccharides

Efficient preparations of thioglycoside derivatives of l-idose and l-iduronic acid are described. The method avoids the tedious chromatographic separations of furanose and pyranose anomeric mixtures, and affords the thioglycosides in a stereoselective man