71609-39-7

Usage

Derivative of imidazole

A five-membered aromatic ring with two nitrogen atoms The compound is based on the imidazole structure, which is a fundamental building block in many biologically active molecules.

4,5-dihydro-2-[(4-methoxyphenyl)methyl]substituent

A 4,5-dihydro-2-phenylmethyl-imidazole core with a methoxy group attached to the phenyl ring This specific functional group is responsible for the compound's unique properties and potential applications.

Potential applications in medicinal chemistry

Imidazole derivatives have been studied for their various biological activities The compound may have potential uses in the development of new drugs and therapies.

Biological activities

Anti-inflammatory, antimicrobial, antifungal, and anticancer properties The compound has shown promise in various preliminary studies for its ability to combat inflammation, infections, and cancer.

Further research needed

Elucidate its potential pharmacological properties and therapeutic uses More research is required to fully understand the compound's potential and its applications in the pharmaceutical industry.

InChI:InChI=1/C11H14N2O/c1-14-10-4-2-9(3-5-10)8-11-12-6-7-13-11/h2-5H,6-8H2,1H3,(H,12,13)

Upstream product

• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 107-15-3 ethylenediamine 
• 33675-41-1 1-bromo-2-(4-methoxyphenyl)acetylene 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 104-47-2 p-methoxybenzylnitrile 
• 14034-59-4 ethylene diamine mono-p-toluenesulfonic acid salt 

Downstream Products

• 90958-89-7 4-(4-Methoxy-phenyl)-7-nitro-1,2-dihydro-imidazo[1,2-a]quinoxaline 5-oxide 
• 124372-80-1 2,3-dihydro-10-(4-methoxyphenyl)imidazo<1,2-g><1,6>naphthyridin-5(1H)-one 
• 102151-99-5 2-<(-methoxyphenyl)methyl>imidazole 
• 124372-92-5 (2-Chloro-pyridin-3-yl)-[2-(4-methoxy-benzyl)-4,5-dihydro-imidazol-1-yl]-methanone 

Relevant academic research and scientific papers

Semi-empirical computation on mechanism of imidazolines and benzimidazoles synthesis and their QSAR studies

A green, mild and anaerobic synthesis of imidazolines and benzimidazoles from aldehydes and diamines using I2/KI/K2CO3/H2O system has been investigated by semi-empirical methods. The observed efficient direction of the above synthesis has been modeled from a comparison of the energies of four possible transition states arising from mono and di additions of iodines in the configured molecules. In the reaction I1 B is the most favorable transition state [TS] which is shown to be 20 Kcal/mol by PM3 analyses. The resulting trends of relative transition states energies are in excellent agreement with the experimental observations. Also, the bond order, bond length, heat of formation is in good agreement to the formation of product B. In order to establish the suitable mechanism of the reaction a quantitative structure activity relationship analysis has been made using hydrophobicity as the molecular descriptor. In this analysis the values of refractivity, polarizability, hydration energy, electron affinity, ionization potential and dipole moment of the compounds have been correlated with their hydrophobicity which has been taken as the molecular property.

An efficient and one-pot synthesis of imidazolines and benzimidazoles via anaerobic oxidation of carbon-nitrogen bonds in water

The system, I2/KI/K2CO3/H2O, oxidizes carbon-nitrogen bonds for the synthesis of imidazolines and benzimidazoles from aldehydes and diamines under anaerobic conditions in water at 90°C with excellent yields. The process is green, mild and inexpensive.

A novel synthetic method for 2-arylmethyl substituted imidazolines and imidazoles from 2-aryl-1,1-dibromoethenes

Various 2-arylmethylimidazolines were prepared by treating readily available 2-aryl-1,1-dibromoethenes with ethylenediamine under mild conditions and further converted into the corresponding imidazoles smoothly with Swern oxidation. Graphical Abstract