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102153-49-1

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102153-49-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 102153-49-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,1,5 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 102153-49:
(8*1)+(7*0)+(6*2)+(5*1)+(4*5)+(3*3)+(2*4)+(1*9)=71
71 % 10 = 1
So 102153-49-1 is a valid CAS Registry Number.

102153-49-1Downstream Products

102153-49-1Relevant articles and documents

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study

Schiedel, Matthias,Rumpf, Tobias,Karaman, Berin,Lehotzky, Attila,Oláh, Judit,Gerhardt, Stefan,Ovádi, Judit,Sippl, Wolfgang,Einsle, Oliver,Jung, Manfred

, p. 1599 - 1612 (2016/03/05)

Sirtuins are NAD+-dependent protein deacylases that cleave off acetyl but also other acyl groups from the ε-amino group of lysines in histones and other substrate proteins. Dysregulation of human Sirt2 (hSirt2) activity has been associated with the pathogenesis of cancer, inflammation, and neurodegeneration, which makes the modulation of hSirt2 activity a promising strategy for pharmaceutical intervention. The sirtuin rearranging ligands (SirReals) have recently been discovered by us as highly potent and isotype-selective hSirt2 inhibitors. Here, we present a well-defined structure-activity relationship study, which rationalizes the unique features of the SirReals and probes the limits of modifications on this scaffold regarding inhibitor potency. Moreover, we present a crystal structure of hSirt2 in complex with an optimized SirReal derivative that exhibits an improved in vitro activity. Lastly, we show cellular hyperacetylation of the hSirt2 targeted tubulin caused by our improved lead structure.

Studies on 2,4,6-trinitrophenyl substituted naphthalenes. Part 1. Synthesis of nitro- and polynitro-2-(2,4,6-trinitrophenyl)naphthalenes

Bergman, John S.,Duffin, Henry C.,Wells, Clifford H.

, p. 11527 - 11532 (2007/10/02)

Three nitro-, two dinitro, and five trinitro derivatives of 2-(2,4,6-trinitrophenyl)naphthalene have been synthesised using a variety of nitration procedures. Some of these derivatives have also been synthesised from 2-bromonaphthalene via a combination o

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