102163-85-9Relevant academic research and scientific papers
Synthesis of novel diazabicycles and their antiprotozoal activities
Wolkinger, Volker,Weis, Robert,Belaj, Ferdinand,Kaiser, Marcel,Brun, Reto,Saf, Robert,Seebacher, Werner
body text, p. 1166 - 1172 (2010/03/04)
We describe the synthesis of new diaryl substituted diazabicyclo[3.2.1] octanes from diazepanes which were prepared by the reduction of diazepanones. The formation of the bicyclic system was optimized by microwave irradiation and the structures of the new compounds were established by single crystal structure analysis and NMR spectroscopy. All new compounds were tested for their potencies against Plasmodium falciparum K1 and Trypanosoma b. rhodesiense, the causative organisms of malaria tropica and the East African form of sleeping sickness. CSIRO 2009.
