1021647-22-2Relevant academic research and scientific papers
Peptide catalyzed asymmetric conjugate addition reactions of aldehydes to nitroethylene - A convenient entry into γ2-amino acids
Wiesner, Markus,Revell, Jefferson D.,Tonazzi, Sandro,Wennemers, Helma
, p. 5610 - 5611 (2008/12/22)
The peptide H-d-Pro-Pro-Glu-NH2 is a highly effective catalyst for conjugate addition reactions between aldehydes and nitroethylene. Only 1 mol % of H-d-Pro-Pro-Glu-NH2 and a 1.5-fold excess of aldehyde with respect to nitroethylene suffice to obtain γ-nitroaldehydes and, after reduction, monosubstituted γ-nitroalcohols in excellent yields and optical purities. The products can be readily converted into γ2-amino acids, thereby opening an effective direct entry into this important class of compounds. Copyright
