1021684-76-3Relevant academic research and scientific papers
Synthesis and antimicrobial activity of some new 2-substituted aminothiazoles
Sutariya, Bhavin,Raziya,Mohan,Rao, S.V. Sambasiva
, p. 884 - 887 (2008/09/18)
Amino group of thiazole (SMB-1) have been treated with various aromatic aldehydes to get corresponding Schiff bases (SMB-2 to SMB-9). These Schiff bases have been then reacted with chloroacetyl chloride to get corresponding azetidinones (SMB-2a to SMB-9a). The structures of all these compounds have been established on the basis of analytical and spectral data. Compounds SMB-1, SMB-2 and SMB-6 are comparable with standard drug ampicillin against S. aureus and S. epidermidis. Compounds SMB-1, SMB-2, SMB-6 and SMB-6a are comparable with ampicillin against E. coli and K. pneumoniae. Compounds SMB-1 and SMB-6 show good activity as compared to standard drug micanazole nitrate against C. albicans and SMB-1 activity is comparable with micanazole nitrate against A. niger.
