1021687-77-3Relevant academic research and scientific papers
CeCl3·7H2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction
Dai, Yan,Li, Bin Dong,Quan, Heng Dao,Lü, Chun Xu
, p. 31 - 34 (2010)
Cerium trichloride heptahydrate (CeCl3·7H2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone. This protocol has advantages of high yield, no environmental pollution, mild condition, and simple work-up procedure.
Choline-based biodegradable ionic liquid catalyst for Mannich-type reaction
Huan, Peng,Yulin, Hu,Rong, Xing,Dong, Fang
, p. 1855 - 1860 (2016/12/16)
A three-component Mannich-type reaction of aromatic aldehydes, ketones, and amines was catalyzed by a novel choline-based acidic ionic liquid. The proposed catalyst was a Lewis-Br?nsted dual acid catalyst as well as water-tolerant. The β-amino carbonyl compounds were obtained at room temperature in reasonable to good yields ranging from 63 to 98%. After the reaction, the catalyst could be recycled and reused for 5 times without obvious decrease of the yield. Further, the catalyst was environment-friendly with a significant biodegradation rate. [Figure not available: see fulltext.]
A magnetic solid sulfonic acid modified with hydrophobic regulators: An efficient recyclable heterogeneous catalyst for one-pot aza-Michael-type and Mannich-type reactions of aldehydes, ketones, and amines
Movassagh, Barahman,Tahershamsi, Leili,Mobaraki, Akbar
, p. 1851 - 1854 (2015/03/30)
Two convenient green protocols for the synthesis of β-amino ketones have been developed which involve one-pot aza-Michael-type and Mannich-type reactions of a series of aldehydes, ketones, and amines in the presence of a catalytic amount of the magnetic solid sulfonic acid catalyst, Fe3O4@SiO2@Me&Et-PhSO3H, at room temperature. The catalyst can be reused four times without loss of activity.
Dipyridine copper chloride-catalysed one-pot synthesis of β;-amino carbonyl compounds via Mannich reaction
Madhav, Janganati Venu,Someshwar, Pola,Kumar, Vanam Naveen,Rajitha, Bavanthula
experimental part, p. 201 - 202 (2009/08/07)
CuPy2Cl2-catalysed Mannich reaction of aromatic aldehyde, aromatic amine, and acetophenone proceeded smoothly in water to afford the corresponding β-amino carbonyl compounds in excellent yields.
