102169-52-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydrazinocarbonyl-benzenesulfonamide is used as a carbonic anhydrase inhibitor for treating conditions such as glaucoma, epilepsy, and altitude sickness. Its ability to inhibit carbonic anhydrase enzymes can help regulate the body's acid-base balance and reduce intraocular pressure in glaucoma patients.
Used in Cancer Research:
2-Hydrazinocarbonyl-benzenesulfonamide is used as a potential anti-cancer agent in cancer research. Its hydrazine and sulfonamide groups may contribute to its anti-tumor activity, making it a candidate for further investigation in the development of novel cancer therapies.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-hydrazinocarbonyl-benzenesulfonamide serves as a valuable compound for the synthesis of new drugs and the study of its chemical properties. Its unique structure allows researchers to explore its potential interactions with biological targets and its role in various physiological processes.

InChI:InChI=1/C7H9N3O3S/c8-10-7(11)5-3-1-2-4-6(5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)

Upstream product

• 81-07-2 saccharin 
• 57683-71-3 methyl 2-(aminosulfonyl)benzoate 

Relevant academic research and scientific papers

Carbonic anhydrase inhibitors: Synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating hydrazino moieties

Targeting proteins overexpressed in hypoxic tumors is as an important means of controlling cancer disease. One such protein is the carbonic anhydrase (CA) isoenzyme IX, which in some types of tumors is overexpressed 150-200-fold. We report here a series of sulfonamide derivatives, prepared from 2-carbohydrazido- and 4-carbohydrazido-benzenesulfonamides, which were further derivatized by reaction with aryl isocyanates or arylsulfonyl isocyanates. Several low nanomolar CA IX inhibitors were detected in this way. SAR is discussed for the diverse types of inhibitors and their affinity for different isozymes, with the aim of obtaining isozyme-specific CA IX inhibitors, with putative applications as antitumor drugs.

Convenient synthesis, antibacterial activity, and crystal structure of some biologically important hydrazinecarbonyl benzenesulfonamides

Microwave-assisted synthesis of a series of hydrazinecarbonyl benzenesulfonamides (5a-r) is reported, and the products have been characterized by nuclear magnetic resonance and Fourier-transform infrared spectral techniques. A comparison with the conventi

Microwave synthesis, crystal structure and spectroscopic investigations of 2-{[(2E)-(2-chlorobenzylidene) hydrazine] carbonyl} benzenesulfonamide and 2-({[(2E)-2-[4-(dimethylamino) benzylidene] hydrazine} carbonyl) benzenesulfonamide

The compounds 2-{[(2E)-(2-chlorobenzylidene) hydrazine] carbonyl} benzenesulfonamide 5a and 2-({[(2E)-2-[4- (dimethylamino)benzylidene] hydrazine} carbonyl) benzenesulfonamide 5b have been synthesized by microwave heating and characterized by NMR, FT-IR a