102170-52-5

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-5-CHLORO-4-METHYL-ANILINE is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties. Its presence in the molecular structure can contribute to the development of new drugs with specific therapeutic effects.
Used in Dye Industry:
In the dye industry, 2-BROMO-5-CHLORO-4-METHYL-ANILINE is utilized as a key component in the production of dyes with specific color characteristics. Its chemical structure allows for the creation of dyes with unique properties, such as colorfastness and resistance to fading.
Used in Agrochemical Industry:
2-BROMO-5-CHLORO-4-METHYL-ANILINE is employed in the agrochemical sector for the development of pesticides and other agricultural chemicals. Its chemical properties can be harnessed to create effective and targeted solutions for pest control and crop protection.
Safety Precautions:
When working with 2-BROMO-5-CHLORO-4-METHYL-ANILINE, it is crucial to follow proper safety procedures to minimize potential health and environmental risks. This includes wearing appropriate protective equipment, such as gloves, goggles, and respirators, and working in a well-ventilated area to prevent exposure to harmful fumes or dust. Additionally, proper storage and disposal methods should be adhered to, ensuring that the compound is handled and contained safely throughout its lifecycle.

InChI:InChI=1/C7H7BrClN/c1-4-2-5(8)7(10)3-6(4)9/h2-3H,10H2,1H3

Upstream product

• 95-74-9 3-chloro-p-toluidine 
• 7149-79-3 N-(3-chloro-4-methylphenyl)acetamide 
• 116010-06-1 N-(2-bromo-5-chloro-4-methylphenyl)acetamide 

Downstream Products

• 289686-80-2 2-cyano-5-chloro-4-methylaniline 
• 289687-06-5 tert-butyl 4-[N-[7-chloro-4-oxo-2-piperidin-1-ylmethyl-3-piperidinocarbonylmethyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate 
• 1026405-52-6 4-{[7-chloro-4-oxo-3-(2-oxo-2-piperidin-1-yl-ethyl)-2-piperidin-1-ylmethyl-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoic acid 
• 289687-05-4 tert-butyl 4-[N-[7-chloro-3-diethylcarbamoylmethyl-4-oxo-2-piperidin-1-ylmethyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate 
• 1027938-29-9 4-[(7-chloro-3-diethylcarbamoylmethyl-4-oxo-2-piperidin-1-ylmethyl-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoic acid 

Relevant academic research and scientific papers

COMPOUNDS AS CCRI ANTAGONISTS

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.

Anti-quinazoline compounds

Dihydroquinazoline derivatives of the formula where R3is —(CH2)p—A where p is from 1 to 4 and A is a 5- or 6-membered N-containing heterocyclic ring attached via the N atom or A is —NA′A″ wherein A′ and A″ are the same or different and are each a C1-C4alkyl group or their pharmaceutically acceptable salts possessing anti-cancer activity.

The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent

4-[N-[7-Bromo-2-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl] -N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide (CB30865) is a quinazolin-4-one antitumor agent whose high growthinhibitory activity (W1L2 IC50 = 2.8 ± 0.50 nM) is believed to have a folate-independent locus of action. In addition, CB30865 represents a class of compounds with unique biochemical characteristics such as a delayed, non-phase specific, cell-cycle arrest. The low aqueous solubility of CB30865 prompted a search for more water-soluble analogues for in vivo evaluation of this class of compounds. It was thought that aqueous solubility could be increased by the introduction of amino functionalities at the 2-position of the quinazolin-4-one ring. A variety of compounds (5a-j, 31a-c, 32, and 33) were synthesized in a linear fashion starting from 3-chloro-4-methylaniline. Most of these compounds (e.g., 5a, 5b, 5g) were significantly more water-soluble than CB30865 (636 μM for 5a at pH 6 and 992 μM for 5g at pH 6). In addition, some of them were up to 6-fold more cytotoxic than CB30865 (e.g., for 5a, W1L2 IC50 = 0.49 ± 0.24 nM) and retained its novel biochemical characteristics.