102170-52-5

Basic information

• Product Name: 2-BROMO-5-CHLORO-4-METHYL-ANILINE
• Synonyms: 2-BROMO-5-CHLORO-4-METHYL-ANILINE;4-Amino-5-bromo-2-chlorotoluene;2-Bromo-5-chloro-4-methyl-phenylamine
• CAS NO: 102170-52-5
• Molecular Formula: C₇H₇BrClN
• Molecular Weight: 220.49
• Product Categories: Amines;blocks;Bromides
• Mol File: 102170-52-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 281.3 °C at 760 mmHg
• Flash Point: 123.9 °C
• Appearance: /
• Density: 1.619 g/cm³
• Vapor Pressure: 0.0036mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.91±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-5-CHLORO-4-METHYL-ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-CHLORO-4-METHYL-ANILINE(102170-52-5)
• EPA Substance Registry System: 2-BROMO-5-CHLORO-4-METHYL-ANILINE(102170-52-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 102170-52-5(Hazardous Substances Data)

Usage

General Description

2-BROMO-5-CHLORO-4-METHYL-ANILINE is a chemical compound that consists of a benzene ring with a bromine atom at the 2 position, a chlorine atom at the 5 position, and a methyl group at the 4 position. It is commonly used in the synthesis of pharmaceuticals, dyes, and agrochemicals. 2-BROMO-5-CHLORO-4-METHYL-ANILINE is considered to be potentially hazardous and should be handled with care due to its potential health and environmental effects. It is important to follow proper safety procedures when working with 2-BROMO-5-CHLORO-4-METHYL-ANILINE, including wearing appropriate protective equipment and working in a well-ventilated area.

InChI:InChI=1/C7H7BrClN/c1-4-2-5(8)7(10)3-6(4)9/h2-3H,10H2,1H3

Upstream product

• 95-74-9 3-chloro-p-toluidine 
• 7149-79-3 N-(3-chloro-4-methylphenyl)acetamide 
• 116010-06-1 N-(2-bromo-5-chloro-4-methylphenyl)acetamide 

Downstream Products

• 289687-06-5 tert-butyl 4-[N-[7-chloro-4-oxo-2-piperidin-1-ylmethyl-3-piperidinocarbonylmethyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate 
• 1026405-52-6 4-{[7-chloro-4-oxo-3-(2-oxo-2-piperidin-1-yl-ethyl)-2-piperidin-1-ylmethyl-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoic acid 
• 289687-05-4 tert-butyl 4-[N-[7-chloro-3-diethylcarbamoylmethyl-4-oxo-2-piperidin-1-ylmethyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate 
• 1027938-29-9 4-[(7-chloro-3-diethylcarbamoylmethyl-4-oxo-2-piperidin-1-ylmethyl-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoic acid 
• 289687-07-6 tert-butyl 4-[N-[7-chloro-3-methoxycarbonylmethyl-4-oxo-2-piperidin-1-ylmethyl-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate 
• 289686-98-2 tert-butyl 4-[N-[7-chloro-3-methyl-4-oxo-2-(4-phenylpiperazin-1-ylmethyl)-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate 
• 289686-97-1 tert-butyl 4-[N-[7-chloro-3-methyl-2-(4-(2-hydroxyethyl)piperazin-1-ylmethyl)-4-oxo-3,4-dihydroquinazolin-6-ylmethyl]-N-(prop-2-ynyl)amino]benzoate 
• 289715-28-2 CB 300919 

Relevant articles and documents

COMPOUNDS AS CCRI ANTAGONISTS

A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically for treatment of diseases and conditions in which CCR-1 is implicated, e.g. inflammatory diseases.

The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent

4-[N-[7-Bromo-2-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl] -N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide (CB30865) is a quinazolin-4-one antitumor agent whose high growthinhibitory activity (W1L2 IC50 = 2.8 ± 0.50 nM) is believed to have a folate-independent locus of action. In addition, CB30865 represents a class of compounds with unique biochemical characteristics such as a delayed, non-phase specific, cell-cycle arrest. The low aqueous solubility of CB30865 prompted a search for more water-soluble analogues for in vivo evaluation of this class of compounds. It was thought that aqueous solubility could be increased by the introduction of amino functionalities at the 2-position of the quinazolin-4-one ring. A variety of compounds (5a-j, 31a-c, 32, and 33) were synthesized in a linear fashion starting from 3-chloro-4-methylaniline. Most of these compounds (e.g., 5a, 5b, 5g) were significantly more water-soluble than CB30865 (636 μM for 5a at pH 6 and 992 μM for 5g at pH 6). In addition, some of them were up to 6-fold more cytotoxic than CB30865 (e.g., for 5a, W1L2 IC50 = 0.49 ± 0.24 nM) and retained its novel biochemical characteristics.