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1021878-08-9

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1021878-08-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1021878-08-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,1,8,7 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1021878-08:
(9*1)+(8*0)+(7*2)+(6*1)+(5*8)+(4*7)+(3*8)+(2*0)+(1*8)=129
129 % 10 = 9
So 1021878-08-9 is a valid CAS Registry Number.

1021878-08-9Downstream Products

1021878-08-9Relevant articles and documents

Versatile zirconium reductants and carbon-carbon coupling agents selectively accessible from the 2:1 molar aggregate of n-butyllithium and zirconium(IV) salts

Eisch, John J.,Gitua, John N.,Yu, Kun

, p. 3523 - 3530 (2011)

In previous studies of transition metal alkyls the 2:1 molar aggregate of n-butyllithium and zirconium(IV) salts has been found to react both with benzylic hydrocarbons and aromatic carbonyl derivatives in diverse and useful ways. In the present study the reactions of the aggregates, 2nBuLi· ZrE4 (E = Cl, OEt), with benzaldehyde have involved carbometallation, hydrometallation and reductive dimerization (paths 1-3) in THF and were selectively achievable by temperature control alone. First, at -78 °C benzaldehyde underwent carbolithiation to give upon hydrolysis 1-phenyl-1-pentanol. However, short-term reaction times and prompt D 2O quenching revealed that with Zr(OEt)4 both benzaldehyde and 1-phenyl-1-pentanol were deuteriated, consistent with the presence of a phenyl(lithioxy)carbene intermediate. The observed dimerization of benzaldehyde to benzyl benzoate by lithium 2,2,6,6-tetramethylpiperidide is also consistent with such a phenyl(lithioxy)carbene intermediate. Second, at 25 °C the 2nBuLi·ZrE4 aggregate reduced benzaldehyde exclusively to benzyl alcohol, which observation is consistent with the formation of the hydrozirconating agent, H2ZrE2. Third, heating the aggregate at reflux and subsequent reaction with benzaldehyde produced solely the reduced dimer, 1,2-diphenyl-1,2-ethanediol with high stereoselectivity: E = Cl, rac/meso of 93:7 and E = OEt, rac/meso of 100:0. The proposed mechanism involves the formation of ZrE2, the epizirconation of benzaldehyde and the insertion of the second benzaldehyde into the zirconaoxacyclopropane under steric control. Finally, the high selectivity in hydrozirconation and reductive dimerization shown by 2nBuLi·ZrE4 appears at this time to be superior to that attainable with analogous titanium or hafnium aggregates. The aggregate 2 nBuLi·ZrE4 (E = Cl, OEt) in THF undergoes highly selective reactions with benzaldehyde controllable by temperature: 1) at -78 °C carbolithiation gives 1-phenyl-1-pentanol; 2) at 25 °C benzyl alcohol is exclusively formed; and 3) after reflux reductive dimerization to the glycol by ZrE2 takes place with high selectivity (rac/meso ≈ 95:5). Copyright

Efficient and convenient heterogeneous palladium-catalyzed regioselective deuteration at the benzylic position

Kurita, Takanori,Hattori, Kazuyuki,Seki, Saori,Mizumoto, Takuto,Aoki, Fumiyo,Yamada, Yuki,Ikawa, Kanoko,Maegawa, Tomohiro,Monguchi, Yasunari,Sajiki, Hironao

, p. 664 - 673 (2008/12/21)

The Pd/C-catalyzed efficient and regioselective hydrogen-deuterium (H-D) exchange reaction on the benzylic site proceeded in D2O in the presence of a small amount of H2 gas. The use of the Pd/C-ethylenediamine complex [Pd/C(en)] as a catalyst instead of Pd/C led to the efficient deuterium incorporation into the benzylic site of Obenzyl protective groups without hydrogenolysis. These H-D exchange reactions provide a post synthetic and D2-gas-free deuterium-labeling method on a wide variety of benzylic sites using D2O as the deuterium source and heterogeneous Pd/C or Pd/C(en) as a reusable heterogeneous palladium catalyst under mild and neutral conditions.

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