1021880-33-0Relevant academic research and scientific papers
A cytotoxic bis(carbene)gold(I) complex of ferrocenyl complexes: Synthesis and structural characterisation
Horvath, Ulrike E. I.,Bentivoglio, Gino,Hummel, Michael,Schottenberger, Herwig,Wurst, Klaus,Nell, Margo J.,Van Rensburg, Constance E. J.,Cronje, Stephanie,Raubenheimer, Helgard G.
, p. 533 - 539 (2008)
The N-heterocyclic carbene (NHC) precursors 1-[(E)-2-butenyl]-3-(4- ferrocenylphenyl)imidazolium bromide (2) and 1-[(E)-2-butenyl]-3-(4- ferrocenylphenyl)imidazolium tetrafluoroborate (3) were derived from 1-(4-ferrocenylphenyl)imidazole. Ferrocenyl complex 3 reacts with Ag 2O and chloro(dimethylsulfide)gold(i) in the presence of tetraethylammonium chloride to produce the mixed metal species bis{1-[(E)-2-butenyl]-3-(4-ferrocenylphenyl)-2H-imidazol-2-ylidene}gold(i) tetrafluoroborate (4). Single crystal X-ray structure analyses of 1, 3 and 4 indicate that the NCHN-hydrogen in 3 is hydrogen bonded to the BF 4- anion [C(H1)...F, 3.265(4) A], as is also reflected in the position of its 1H NMR chemical shift. Cytotoxicity studies show that complex 4 is selective for cancer cells and active against the tumour cell lines Jurkat and MCF 7. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
Application of ferrocenylimidazolium salts as catalysts for the transfer hydrogenation of ketones
Ikhile, Monisola I.,Bala, Muhammad D.,Nyamori, Vincent O.,Ngila, J. Catherine
, p. 98 - 108 (2013/03/13)
Ferrocenylimidazolium salts with methylene and phenyl groups bridging the ferrocenyl and alkylimidazolium moieties were synthesized and characterized by spectroscopic and analytical methods. Crystal structures of two new compounds are also reported. Cyclic voltammetry was used to analyze the influence of the two bridging groups or spacers on electrochemical properties of the salts relative to the shifts in the formal electrode or peak potentials (E0 or E1/2) of the ferrocene/ferrocenium redox couple. Results from this study showed that all the salts exhibited higher electrode potentials relative to ferrocene, which is due to the electron-withdrawing effect of the imidazolium ion on the ferrocenyl moiety. Application of the salts as catalysts in transfer hydrogenation of ketones resulted in high conversion of saturated ketones to corresponding alcohols and turnover numbers as high as 1880. The catalysts were chemoselective towards reduction of the C=C bonds of conjugated 3-penten-2-one and 4-hexen-3-one to yield saturated ketones, while unconjugated 5-hexen-2-one was hydrogenated to an unsaturated alcohol. Copyright
Phosphino imidazoles and imidazolium salts for Suzuki C-C coupling reactions
Milde, Bianca,Schaarschmidt, Dieter,Rueffer, Tobias,Lang, Heinrich
, p. 5377 - 5390 (2012/05/20)
The consecutive syntheses of imidazoles 1-(4-X-C6H 4)-4,5-R2-cC3HN2 (3a, X = Br, R = H; 3b, X = I, R = Me; 3c, X = H, R = Me; 5, X = Fc, R = H; 7, X = CCFc, R = H; 9, X = C6Hsub
