102191-89-9

Upstream product

• 20291-99-0 t-butyl mercaptoacetate 
• 188560-12-5 tert-butoxy-carbonyl-methane-sulphenyl chloride 
• 71901-63-8 tert-butyl diazopyruvate 
• 102191-87-7 tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(tert-butoxycarbonylmethyl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate 

Relevant academic research and scientific papers

1-dethia-2-thia-cephalosporanic acids

Novel 1-dethia-2-thia-cephalosporanic acid derivatives of the formula STR1 wherein R is selected from the group consisting of STR2 Ra is an organic radical, Ri and Rj are individually selected from the group consisting of hydrogen, aliphatic, aromatic and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted cycle or Rb NH--, Rb is optionally substituted carbocyclic or heterocyclic aryl, R1 and --COM are as defined in the specification, R4 is hydrogen or methoxy, n2 is 0, 1 or 2 and their non-toxic, pharmaceutically acceptable acid addition salts in racemic or optically active form having antibiotic activity and their preparation and novel intermediates.

SYNTHESIS OF 3-(ALKYL AND ARYL)THIO-2-ISOCEPHEMS

Synthesis of 3-S-substituted isocephems has been carried out in a convergent way using readily available intermediates such as 4-mercaptomethylazetidinone 3 and chloropyruvates 4 prepared by the reaction of sulfenyl chlorides with t-butyl diazopyruvate.Du