20291-99-0

Usage

Uses

Used in Pharmaceutical Industry:
Acetic acid, mercapto-, 1,1-dimethylethyl ester is used as a reagent in the synthesis of enantiopure thioesters, such as (R)-2-(2-benzamidopropanoylthio)acetic. These enantiopure thioesters are key substrates for screening the sensitivity of penicillin binding proteins to inhibitors, which is crucial for the development of new antibiotics and understanding the mechanisms of action of existing ones.
Used in Chemical Synthesis:
In the field of chemical synthesis, Acetic acid, mercapto-, 1,1-dimethylethyl ester serves as a valuable intermediate for the preparation of various organic compounds. Its unique structure allows for selective reactions and transformations, making it a useful building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Research and Development:
Acetic acid, mercapto-, 1,1-dimethylethyl ester is also utilized in research and development settings to explore its potential applications and properties. Its reactivity and functional groups make it an interesting candidate for studying new reaction mechanisms, developing novel synthetic routes, and discovering new compounds with potential applications in various industries.

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 76834-15-6 S-acetyl thioglycolate de tert-butyle 
• 107-59-5 tert-Butyl chloroacetate 
• 27240-57-9 O-ethyl S-(tert-butoxycarbonyl)methyl dithiocarbonate 

Downstream Products

• 27240-61-5 Phenoxycarbonylsulfanyl-acetic acid tert-butyl ester 
• 27249-58-7 Phenoxythiocarbonylsulfanyl-acetic acid tert-butyl ester 
• 102191-89-9 tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(tert-butoxycarbonylmethyl)thio>-1-dethia-2-thia-3-cephem-4-carboxylate 
• 102191-87-7 tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(tert-butoxycarbonylmethyl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate 
• 1610614-76-0 tert-butyl 2-[2-chloro-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate 
• 58264-68-9 5-methoxy-6-methylbenzo[b]thiophene-2-carboxylic acid 
• 1413285-58-1 {2-chloro-4-[4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrol-2-yl]phenylsulfanyl}acetic acid tert-butyl ester 
• 1413285-53-6 {4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylphenylsulfanyl}acetic acid tert-butyl ester 
• 102652-81-3 tert-butyl <<4(S)-acetoxy-3(S)-(phenoxyacetamido)-2-oxo-1-azetidinyl>thio>acetate 
• 102652-80-2 ((2S,3S)-2-Methyl-4-oxo-3-phenylacetylamino-azetidin-1-ylsulfanyl)-acetic acid tert-butyl ester 
• 100239-04-1 tert-butyl <<4(S)-methyl-3(S)-((benzyloxy)formamido)-2-oxo-1-azetidinyl>thio>acetate 
• 27249-62-3 Phenylsulfanylthiocarbonylsulfanyl-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AS INHIBITORS OF KRAS G12C

Provided are heterocyclic compounds as inhibitors of the KRAS G12C and uses thereof. Specifically, provided are the compounds of any of formula I to XI or stereoisomers, enantiomers, atropoisomerics or pharmaceutically acceptable salts thereof. Definition of each group in the formula can be found in the specification for details.

Synthesis of an enantiopure thioester as key substrate for screening the sensitivity of penicillin binding proteins to inhibitors

The synthesis of the enantiopure thioester (R)-2-(2-benzamidopropanoylthio)acetic acid was developed. After the exploration of several activation methods, reaction conditions were found for the formation of the thioester bond in the presence of propylphosphonic anhydride with high enantioselectivity (ee > 99%). The thioester activity of Penicillin Binding Proteins is helpful in research programs looking for new lead structures to overcome the problem of bacterial resistance.

Novel sirtuin inhibitory warheads derived from the Nε-acetyl-lysine analog l-2-amino-7-carboxamidoheptanoic acid

Built upon the catalytic mechanism-based pan-SIRT1/2/3 inhibitory warhead l-2-amino-7-carboxamidoheptanoic acid (l-ACAH, a close structural analog of Nε-acetyl-lysine) that our laboratory discovered recently, in the current study, its carboxami

HETEROCYCLIC AMIDES AS ROCK INHIBITORS

The present invention relates to new kinase inhibitors of formula (I), more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: Structure-activity relationships and selective binding patterns

The substituted thieno[2,3-d]pyrimidine 3 (Org 41841), a partial agonist for the luteinizing hormone/choriogonadotropin receptor (LHCGR) and the closely related thyroid-stimulating hormone receptor (TSHR), was fundamentally altered, and the resulting anal

1-dethia-2-thia-cephalosporanic acids

Novel 1-dethia-2-thia-cephalosporanic acid derivatives of the formula STR1 wherein R is selected from the group consisting of STR2 Ra is an organic radical, Ri and Rj are individually selected from the group consisting of hydrogen, aliphatic, aromatic and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted cycle or Rb NH--, Rb is optionally substituted carbocyclic or heterocyclic aryl, R1 and --COM are as defined in the specification, R4 is hydrogen or methoxy, n2 is 0, 1 or 2 and their non-toxic, pharmaceutically acceptable acid addition salts in racemic or optically active form having antibiotic activity and their preparation and novel intermediates.

Benzimidazole compounds

Novel imidazoles of the formula STR1 and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.

The Synthesis of Substituted thio>acetic Acids

The synthesis of substituted thio>acetic acids (6, thiamazins) is described.Various substituted 3(S)-(acylamino)-2-azetidinones were sulfenylated with tert-butyl (phtalimidothio)acetate.Deprotection of the tert-butyl ester with trifluoroacetic acid provided the title compounds.In sharp contrast to their oxygen analogues (oxamazins), the thiamazins were devoid of biological activity.