1021917-02-1

Basic information

• Product Name: (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol
• Synonyms: (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol
• CAS NO: 1021917-02-1
• Molecular Weight: 334.344
• Mol File: 1021917-02-1.mol

Chemical Properties

• CAS DataBase Reference: (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol(1021917-02-1)
• EPA Substance Registry System: (Z)-5-(2-fluoro-2-(3,4,5-trimethoxyphenyl)vinyl)-2-methoxyphenol(1021917-02-1)

Safety Data

• Hazardous Substances Data: 1021917-02-1(Hazardous Substances Data)

Upstream product

• 621-59-0 isovanillin 
• 1056950-83-4 5-[(E,Z)-2-fluoro-2-(3,4,5-trimethoxy-phenyl)-vinyl]-2-methoxy-phenol 

Relevant articles and documents

Spontaneous resolution of julia-kocienski intermediates facilitates phase separation to produce Z - And e -monofluoroalkenes

The monofluoroalkene motif is important in drug development as it serves as a peptide bond isostere and is found in a number of biologically active compounds with various pharmacological activities. Direct olefination of carbonyl compound is a straightfor

Synthesis of Bromoundecyl Resorc[4]arenes and Applications of the Cone Stereoisomer as Selector for Liquid Chromatography

As an extension of our studies on the multifaceted properties of C-alkylated resorc[4]arenes, we planned to immobilize on a solid support resorc[4]arenes with C11-long side chains in the lower rim. To this purpose, we synthesized two conformationally diverse resorc[4]arenes containing a bromoundecyl moiety in the four axial pendants. The cone stereoisomer 6a (30% yield) was selected for the reaction with an aminopropylated silica gel (APSG) obtained from spherical Kromasil Si 100, 5 μm particles, to give the corresponding immobilized SP-C11-resorc[4]arene system. The resulting polar-embedded stationary phase was fully characterized and investigated in the HPLC discrimination of the E/Z stereoisomers of naturally occurring and semisynthetic combretastatins, a family of (Z)-stilbene anticancer drugs. The chair stereoisomer 6b (20% yield), when submitted to X-ray diffraction analysis, showed a noteworthy self-assembly in the crystal lattice, with intercalated hydrophobic and polar layers as a result of intermolecular Br···O halogen bond interactions, according to a unique stacking motif. The potential and versatility of the SP-C11-resorc[4]arene stationary phase were shown as well in the separation of highly polar natural products (namely, flavonoids), under reversed-phase (RP) conditions, and of fullerenes C60 and C70, by using apolar solvents as mobile phases.

Reagent for preparing high-selectivity monofluoroolefin

The invention provides a reagent for preparing high-selectivity monofluoroolefin, particularly a reagent capable of preparing monofluoroolefin at high selectivity and a method for preparing monofluoroolefin by using the reagent. The method has the advanta

Synthesis and biological activity of fluorinated combretastatin analogues

With the aim of understanding the influence of fluorine on the double bond of the cis-stilbene moiety of combretastatin derivatives and encouraged by a preliminary molecular modeling study showing a different biological environment on the interaction site