102197-56-8Relevant articles and documents
First total synthesis of piperodione and analogs
Sommerwerk, Sven,Kern, Simone,Heller, Lucie,Csuk, René
, p. 6243 - 6244 (2014)
Piperodione (3), a secondary metabolite previously isolated from the Javanese pepper plant Piper retrofractum in 0.0002% isolated yield was synthesized in a convergent strategy utilizing a Mannich and a Stetter reaction. An over-all yield of 76% could be achieved. Several analogs were prepared by this synthetic sequence. None of the compounds showed a significant cytotoxicity for human tumor cells (photometric sulforhodamine B assay).