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NSC525120, also known as 5-cyclopropyl-2-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyrimidin-3(2H)-one, is a chemical compound belonging to the thieno[2,3-d]pyrimidine class, which is recognized for its potential antineoplastic properties. NSC525120 has been identified as a potential inhibitor of key signaling pathways such as phosphatidylinositol 3-kinases (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR), which play crucial roles in cell growth, survival, and metabolism.
Used in Pharmaceutical Industry:
NSC525120 is used as an antineoplastic agent for its potential to inhibit the PI3K/Akt/mTOR signaling pathways, which are often dysregulated in various cancers, contributing to uncontrolled cell growth and survival. Its ability to target these pathways makes it a promising candidate for the treatment of different cancer types.
Used in Cancer Research:
In preclinical studies, NSC525120 has demonstrated promise in treating various types of cancer, including breast, colon, and pancreatic cancer. It is used as a research tool to further explore its therapeutic potential and to understand the mechanisms by which it exerts its anticancer effects.
Used in Drug Development:
NSC525120 is utilized in the development of novel therapeutic agents targeting the PI3K/Akt/mTOR pathways. Its potential as a lead compound in the creation of new drugs for cancer treatment is being investigated, with the aim of improving patient outcomes and overcoming resistance to existing therapies.
Further research is necessary to fully understand the potential of NSC525120 as a therapeutic agent, including its safety, efficacy, and optimal dosing regimens. As our understanding of its properties and mechanisms of action grows, so too will its applications in the fight against cancer.

10221-08-6

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10221-08-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 10221-08-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,2 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 10221-08:
(7*1)+(6*0)+(5*2)+(4*2)+(3*1)+(2*0)+(1*8)=36
36 % 10 = 6
So 10221-08-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H7Cl3/c9-4-6-1-2-7(5-10)8(11)3-6/h1-3H,4-5H2

10221-08-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-1,4-bis(chloromethyl)benzene

1.2 Other means of identification

Product number -
Other names 2-chloro-1,4-bis-chloromethyl-benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10221-08-6 SDS

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