102211-98-3Relevant academic research and scientific papers
A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent
Anselmi, Silvia,Liu, Siyu,Kim, Seong-Heun,Barry, Sarah M.,Moody, Thomas S.,Castagnolo, Daniele
, p. 156 - 161 (2021/01/14)
A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.
A mild, chemoselective oxidation of sulfides to sulfoxides using o-iodoxybenzoic acid and tetraethylammonium bromide as catalyst
Shukla, Vidyanand G.,Salgaonkar, Paresh D.,Akamanchi, Krishnacharya G.
, p. 5422 - 5425 (2007/10/03)
A mild, selective, and high-yielding method for oxidation of sulfides to sulfoxides using IBX and tetraethylammonium bromide in a variety of solvents is described. The method offers the advantage of short reaction times, no over-oxidation to sulfones, and compatibility to a wide range of functional groups.
Rearrangement of Benzylically Lithiated Methylaryl Alkyl Sulfones
Madaj, Edmund J.,Snyder, Donald M.,Truce, William E.
, p. 3466 - 3469 (2007/10/02)
Lithiathion of appropriate methylaryl alkyl sulfones is followed by migration of the alkyl group from sulfur to the benzylic carbon.Product studies, relative reactivities, and crossover experiments are consistent with a radical-radical anion chain process for this rearrangement.
