38160-59-7

Upstream product

• 123-73-9 trans-Crotonaldehyde 
• 108-98-5 thiophenol 
• 882-33-7 diphenyldisulfane 
• 123-73-9 crotonaldehyde 
• 930-69-8 sodium thiophenolate 

Downstream Products

• 138092-08-7 2,2-Dimethyl-3-hydroxy-5-(phenylthio)hexanoic acid methyl ester 
• 138092-08-7 2,2-Dimethyl-3-hydroxy-5-(phenylthio)hexanoic acid methyl ester 
• 81513-70-4 2-Phenylsulfanyl-heptan-4-ol 
• 62162-25-8 4-(phenylthio)-1-pentene 
• 884598-51-0 4-Phenylsulfanyl-pentanal 
• 90083-82-2 2-Chloro-3-phenylsulfanyl-butyraldehyde 
• 81513-69-1 1-(3-Methoxy-phenyl)-3-phenylsulfanyl-butan-1-ol 
• 884598-67-8 6-(phenylthio)hept-1-en-4-ol 
• 102211-98-3 3-(phenylthio)butan-1-ol 
• 880-13-7 2-hydroxycarbonyl-1-methylethyl phenyl sulfide 
• 1374882-99-1 2-phenyl-5-(2-(phenylthio)propyl)furan 
• 1311381-89-1 2-(3,5-bis(trifluoromethyl)phenyl)-5-(phenylthio)hex-1-en-3-one 
• 220573-64-8 C₁₀H₁₂O₂S 
• 83802-86-2 3-Benzenesulfonyl-butyraldehyde 

Relevant academic research and scientific papers

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

SmI2-mediated reductive cyclization of β-arylthio ketones: A facile and diastereoselective synthesis of thiochroman derivatives

SmI2-mediated reductive cyclization of β-arylthio ketones to generate thiochroman derivatives is not a generally observed process and the reported examples are limited to geminal disubstitution in the substrates. The results of the current stud

Thioboration of α,β-unsaturated ketones and aldehydes toward the synthesis of β-sulfido carbonyl compounds

Herein a direct β-sulfido carbonyl compound synthesis by the easy activation of RS-Bpin reagents with α,β-unsaturated ketones and aldehydes is reported. This convenient methodology can be performed at room temperature with no other additives. The key poin

Ionic liquid/PPh3 promoted cleavage of diphenyl disulfide and diselenide: A straight-forward metal-free one-pot route to the synthesis of unsymmetrical sulfides and selenides

A metal-free cleavage of diphenyl disulfide and diphenyl diselenide has been achieved using ionic liquid/triphenyl phosphine (PPh3) and a convenient protocol for the one-pot synthesis of unsymmetrical sulfides and selenides by condensing 'in situ' generated thiolate or selenate anion with alkyl halides has been developed. In addition, 1,4-conjugate addition of the generated thiolate anions to activated alkenes has also been demonstrated. The ionic liquid, 1-methyl-3-pentyl imidazolium bromide, [pmIm]Br plays a crucial role in promoting the course of the reactions and shows superior activity and selectivity compared to other solvents. The [pmIm]Br has been reused for at least five times without appreciable loss of activity.

Supported cobalt complex-catalysed conjugate addition of indoles, amines and thiols to α,β-unsaturated compounds

A highly active and reusable supported Co(ii) complex on SBA-15 shows an excellent activity and selectivity to target products in aza- and thia-Michael conjugate additions of indoles, amines and thiols to α,β-unsaturated compounds under solventless mild reaction conditions. The Co-catalyst was also highly reusable and comparably more active than related catalysts in the reaction.

Triethylammonium acetate (TEAA): A recyclable inexpensive ionic liquid promotes the chemoselective aza- and thia-Michael reactions

A new, highly efficient, inexpensive, recyclable, mild, convenient, and green protocol for chemoselective aza/thia-Michael addition reactions of amines/thiols to α,β-unsaturated compounds using triethylammonium acetate (TEAA) ionic liquid was developed. The catalyst can be recycled ten times and obviate the need for toxic and expensive catalysts.

Efficient synthesis of β-alkyl/arylsulfanyl carbonyl compounds by In-TMSCl-promoted cleavage of dialkyl/diaryl disulfides and subsequent Michael addition

A convenient and efficient procedure for the synthesis of β-alkyl/arylsulfanyl carbonyl compounds has been developed by a simple one-pot reaction of dialkyl/diaryl sulfides with α,β-unsaturated aldehydes, ketones, carboxylic esters, and nitriles in presence of indium and trimethylsilyl chloride under sonication. Copyright Taylor & Francis Group, LLC.

Borax as an efficient metal-free catalyst for hetero-Michael reactions in an aqueous medium

Borax, a naturally occurring material, very efficiently catalyzed the conjugate addition of thiols, dithiols and amines to α,β-unsaturated ketones, nitriles, amides, aldehydes and esters in an aqueous medium to afford the corresponding Michael adducts in good yields at room temperature. Recycling of the catalyst and scaling up of the reactions are important attributes of this catalysis. The reactions of thiols and dithiols were relatively more facile than those of the corresponding amines. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Indium(I) iodide promoted cleavage of dialkyl disulfides - Application of the Michael addition of thiolate anions to conjugated carbonyl compounds and regioselective ring opening of epoxides

Indium(I) iodide promotes cleavage of dialkyl disulfides generating thiolate anions that then undergo facile addition to α,β-unsaturated ketones, aldehydes, carboxylic esters, and nitriles under neutral conditions producing corresponding β-ketosulfides or β-cyanosulfides. This strategy has also been used for the regioselective nucleophilic ring opening of epoxides by thiolate anions in presence of indium(III) chloride producing corresponding β-hydroxyphenyl sulfides. The reactions are in general, very clean, high yielding, and reasonably fast. Thus, simple and convenient procedures for the synthesis of β-ketosulfides or β-cyanosulfides and β-hydroxyalkyl sulfides have been developed using this cleavage reaction.

Formation of zinc thiolates by reductive cleavage of disulfides with the Zn/AlCl3 system in aqueous media, and their use for Michael addition

A simple, convenient, and efficient one-pot protocol for the reductive cleavage of disulfides and Michael addition to α,β-unsaturated carbonyl compounds mediated by the Zn/AlCl3 system in aqueous media is reported.