1022193-74-3

Basic information

• Product Name: 6-amino-3-{2-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-1,3-oxathiolan-5-yl}-3-hydropyrimidine-2-one
• Synonyms: 6-amino-3-{2-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-1,3-oxathiolan-5-yl}-3-hydropyrimidine-2-one
• CAS NO: 1022193-74-3
• Molecular Weight: 467.664
• Mol File: 1022193-74-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-amino-3-{2-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-1,3-oxathiolan-5-yl}-3-hydropyrimidine-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-3-{2-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-1,3-oxathiolan-5-yl}-3-hydropyrimidine-2-one(1022193-74-3)
• EPA Substance Registry System: 6-amino-3-{2-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]-1,3-oxathiolan-5-yl}-3-hydropyrimidine-2-one(1022193-74-3)

Safety Data

• Hazardous Substances Data: 1022193-74-3(Hazardous Substances Data)

Upstream product

• 71-30-7 Cytosine 
• 139757-72-5 [2-[[tert-butyl(diphenyl)silyl]oxymethyl]-1,3-oxathiolan-5-yl] acetate 
• 125111-27-5 3-((tert-butyldiphenylsilyl)oxy)propane-1,2-diol 
• 115869-43-7 (tert-butyldiphenylsilanyloxy)acetaldehyde 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 134678-17-4 lamivudine 

Relevant articles and documents

PROCESS FOR THE MANUFACTURE OF CIS(-)-LAMIVUDINE

An improved process for the manufacture of Lamivudine. The process involves: (a) resolution of racemic lamivudine (intermediate of formula IX) to cis (±) lamivudine of formula (XII) by forming a crystalline salt and separating the product from an organic solvent by fractional crystallization; (b) resolution of cis (±) lamivudine to cis (?) isomer involving formation of S-Binol adduct of formula XIV.