102222-41-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 94226-56-9 tert-butyl 2-(dibenzylamino)ethanoate 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 103-49-1 dibenzylamine 

Downstream Products

• 94226-67-2 2-Dibenzylamino-3-hydroxy-nonanoic acid tert-butyl ester 
• 113410-10-9 (2S,3S,4S)-4-Benzyloxy-2-dibenzylamino-3-hydroxy-pentanoic acid tert-butyl ester 
• 113410-12-1 (2S,3R,4S)-4-Benzyloxy-2-dibenzylamino-3-hydroxy-pentanoic acid tert-butyl ester 
• 113410-11-0 2-amino-2,5-dideoxy-L-lyxo-pentanoate 
• 113410-09-6 (2R,3R,4S)-4-Benzyloxy-2-dibenzylamino-3-hydroxy-pentanoic acid tert-butyl ester 
• 102222-44-6 4-Benzyloxy-2-dibenzylamino-3-hydroxy-decanoic acid tert-butyl ester 
• 94226-75-2 2-Dibenzylamino-3-hydroxy-4,4-dimethyl-pentanoic acid tert-butyl ester 
• 94226-71-8 3-Cyclohexyl-2-dibenzylamino-3-hydroxy-propionic acid tert-butyl ester 
• 94226-59-2 2-Dibenzylamino-3-hydroxy-butyric acid tert-butyl ester 
• 94226-63-8 2-Dibenzylamino-3-hydroxy-3-phenyl-propionic acid tert-butyl ester 

Relevant academic research and scientific papers

STEREOSELECTIVE SYNTHESIS OF t-BUTYL 2-AMINO-2,5-DIDEOXY-L-LYXO-PENTANOATE: FORMAL SYNTHESIS OF L-DAUNOSAMINE

Enantiomerically pure t-Butyl 2-amino-2,5-dideoxy-L-lyxo-pentanoate 4c is synthesized via the highly diastereoselective MgBr2 mediated addition of dibenzylamino acetate silylketene acetal 2 to O-benzyl lactic aldehyde 3.The synthesis of γ-lactone 5c, a known intermediate in the synthesis of L-daunosamine, is also described.

ACID CATALYSIS IN ALDOL CONDENSATION OF α-AMINO SILYLKETENE ACETALS. DIASTEREOSELECTIVE SYNTHESIS OF α-AMINO-β-HYDROXYACIDS.

The aldol-type condensation between α-dibenzylamino trimethylsilyl ketene acetals and various achiral and chiral aldehydes in the presence of a Lewis acid furnishes α-amino-β-hydroxyacids in moderate yields with preferential C2-C3 th