1022282-99-0

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 34446-64-5 (E)-3-(4-methoxyphenyl)propenoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 2555-37-5 3-acetyl-4-hydroxychromen-2-one 

Downstream Products

• 836678-26-3 3-[1-chloroacetyl-5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-hydroxy-chromen-2-one 
• 836678-28-5 3-[1-hydrazinoacetyl-5-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-hydroxy-chromen-2-one 
• 1017625-38-5 4-hydroxy-3-[5-(4-methoxyphenyl)-1-(4-tolyl)-4,5-dihydro-1H-pyrazol-3-yl]coumarin 
• 1017625-37-4 4-hydroxy-3-[1,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]coumarin 
• 1017625-46-5 4-hydroxy-3-[5-(4-methoxyphenyl)-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-3-yl]coumarin 
• 2748-28-9 4-hydroxy-3-[5-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]coumarin 
• 1017625-36-3 4-hydroxy-3-[5-(4-methoxyphenyl)-1-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-3-yl]coumarin 
• 1192030-25-3 3-[1-(benzothiazol-2-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl]-4-hydroxycoumarin 
• 1240428-16-3 3-[6-(4-fluorophenyl)-4-(4-methoxyphenyl)pyridin-2-yl]-4-hydroxycoumarin 
• 1240428-14-1 3-[6-(4-chlorophenyl)-4-(4-methoxyphenyl)pyridin-2-yl]-4-hydroxycoumarin 
• 1240428-18-5 4-hydroxy-3-[4-(4-methoxyphenyl)-6-(4-nitrophenyl)pyridin-2-yl]coumarin 
• 1240428-20-9 3-[6-(3-coumarinyl)-4-(4-methoxyphenyl)pyridin-2-yl]-4-hydroxycoumarin 

Relevant academic research and scientific papers

A coumarin-chalcone hybrid used as a selective and sensitive colorimetric and turn-on fluorometric sensor for Cd2+ detection

A chalcone-based naked-eye colorimetric chemical sensor, (E)-4-hydroxy-3-(3-(4-methoxyphenyl)acryloyl)-2H-chromen-2-one 1a, was developed for selective and sensitive recognition of Cd2+ in mixed aqueous-organic media. The chemosensor demonstrates a distinct color change as well as a remarkable variation in the absorption and fluorescence enhancement observed in its emission spectra upon interaction with Cd2+. The dual colorimetric and fluorometric responses of the chemosensor 1a towards Cd2+ are attributed to the formation of a 1 : 1, 1a-Cd2+ complex, which eventually affect its optical properties. The association constants for Cd2+ towards receptor 1a obtained from the Benesi-Hildebrand plot and non-linear least square fitting were found to be 9.56 × 105 M-1 and 1.34 (±0.87) × 106 M-1, respectively, with a detection limit of 5.84 × 10-8 M. The fluorescence enhancement of chemosensor 1a upon interaction with Cd2+ was attributed to chelation-enhanced fluorescence (CHEF) occurring at pH 7.0.

Preparation of Furo[3,2-c]coumarins from 3-Cinnamoyl-4-hydroxy-2H-chromen-2-ones and Acyl Chlorides: A Bu3P-Mediated C-Acylation/Cyclization Sequence

A Bu3P-mediated cyclization reaction of 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones though electrophilic addition of acyl chlorides towards the synthesis of highly functionalized furo[3,2-c]coumarins bearing a phosphorus ylide moiety is described. These unprecedented cyclization reaction proceeds under mild reaction conditions within short reaction times (1 min to 1 h), and can be further applied in the synthesis of alkenyl-substituted furo[3,2-c]coumarins by the treatment with carbonyl electrophiles under basic conditions.

A rapid access to new coumarinyl chalcone and substituted chromeno[4,3-c]pyrazol-4(1H)-ones and their antibacterial and DPPH radical scavenging activities

A series of new coumarin derivatives 4 containing a chalcone moiety were synthesized by condensation of 3-acetyl-4-hydroxycoumarin 1 with aryl or heteroaryl aldehydes 2 in the presence of piperidine in chloroform. The interaction of 3-formyl-4-chloro-coumarin 3 with nitrogen compound nucleophiles are described and lead to the corresponding substituted chromen[4,3-c] pyrazol-4-ones 5. The structures of the obtained compounds were established on the basis of IR|1D|2D NMR, while crystal structure of 3-acetyl-4-hydroxy coumarin 1 was determined using X-ray diffraction and further were evaluated for possible antibacterial and antioxidant activities. The coumarinic chalcone 4d has been found to be the most active (IC50 = 2.07 μM) in this study.

Expedious synthesis for α, β-unsaturated coumarin derivatives using boran chelates: A novel class of potential antibacterial and antioxidant agents

A new family of coumarin derivatives (4a-i) containing a chalcone moiety was synthesized by condensation of 3-acetyl-4-difluoro boryloxycoumarin (2) with aryl and heteroaryl aldehydes with piperidine in chloroform. Resulting compounds were characterized by IR, 13C, 1H NMR and UV visible spectroscopy. Compound 3-((2E)-3-(3,4,5-Trimethoxy-phenyl)prop-2-enoyl)- 2(H)-chromen-2-one (4g) was characterized by single crystal X-ray diffraction. The antioxidant and antibacterial activities of the obtained compounds 4a-i was evaluated. The biological activity found for these compounds is discussed against their structural features, physical and chemical properties.

Synthesis and structure of new 3-pyrazolinylcoumarins and 3-pyrazolinyl-2-quinolones

The reactions of substituted 3-cinnamoyl-4-hydroxycoumarins and 3-cinnamoyl-4-hydroxy-2-quinolones with different phenylhydrazines gave 3-hetaryl-1H-4,5-dihydropyrazoles. The product structures were studied by 1H NMR spectroscopy and mass spect

Design and synthesis of a novel series of nonpeptidic HIV-1 protease inhibitors

Using molecular modelling and the X-ray crystal structures of peptide, (1-(naphthoxy-acetyl)-L-histidyl-5(S)-amino-6-cyclohexyl-3 (R),4(R)-dihydroxy-2(R)-isopropylhexanoyl-L-isoleucine N-(2-pyridylmethyl)amide (U-75875) and nonpeptide-derived inhibitors,